FTO和MC4R基因多态性与代谢综合征相关性状的关联研究  

Study on the relationship between MC4R,FTO gene polymorphisms and metabolic syndrome-related phenotypes

作　　者：许志远[1,2] 宋洁云[1] 王海俊[1] 李刚[3] 

机构地区：[1]北京大学公共卫生学院妇女与儿童青少年卫生学系,北京100191 [2]教育部流行病学重点试验室 [3]北京市疾病预防控制中心慢性病防治所

出　　处：《现代预防医学》2012年第8期1866-1870,共5页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(30700668);高等学校博士学科点专项科研基金资助课题(20070001811)

摘　　要：目的探讨FTO基因rs9939609多态性和MC4R基因rs12970134多态性与代谢综合征相关性状之间的相关性。方法从北京市18～79岁常住居民中选取983人,包括肥胖组441名,对照组542名。通过问卷调查、代谢综合征相关性状测量和基因多态性测定,对两个基因多态性和代谢综合征相关性状进行关联分析。结果携带FTO基因rs9939609多态性A等位基因者发生代谢综合征的风险增加为1.53倍(95%CI:1.08～2.15,P=0.02)。携带MC4R基因rs12970134多态性A等位基因者发生肥胖的风险增加为1.42倍(95%CI:1.09～1.84,P=0.01)。每个rs12970134多态性A等位基因使血糖升高0.17mmol/L(95%CI:0.03～0.32,P=0.02)。携带两个以上FTO或MC4R风险等位基因者与没有携带风险等位基因者相比,肥胖发生风险增加为2.04倍(95%CI:1.25～3.33,P=0.004)。结论 FTO基因rs9939609多态性和MC4R基因rs12970134多态性在中国成人中与代谢综合征相关性状存在关联,可为代谢综合征的预防和控制提供理论依据。OBJECTIVE To study relationship between MC4R,FTO gene polymorphisms and metabolic syndrome（MS）-related phenotypes in Chinese adults.METHODS We selected 983 adults aged 18-79 years old in Beijing,including 441 obese and 542 normal-weight individuals.The questionnaire investigation,MS-related phenotypes measurement and genotyping of the rs9939609,rs12970134 polymorphisms were performed.RESULTS The FTO rs9939609 polymorphism was associated with MS（OR=1.53,95%CI=1.08-2.15,P = 0.02）.The MC4R rs12970134 polymorphism was associated with obesity（OR=1.42,95%CI=1.09-1.84,P = 0.01）,fasting plasma glucose level（β=0.17,95%CI=0.03-0.32,P = 0.02）.Compared to individuals carrying no FTO or MC4R risk allele,those with two or more risk alleles would have a 2.04-fold increased susceptibility of developing obesity（95%CI=1.25-3.33,P = 0.004）.CONCLUSION The FTO and MC4R gene polymorphisms were associated with MS-related phenotypes in Chinese adults,which provided theoretical evidence for prevention and control of MS.

关 键 词：FTO MC4R 基因 代谢综合征 肥胖 

分 类 号：R589[医药卫生—内分泌]