This work was supported by grants from the National Natural Science Foundation of China(Grant No.31771283&31771608);the National Institute of Health(R01HD084440).
Background:Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration.However,the expression and function of Mc4r in the mouse limb and digit has not been fully invest...
This work was partially supported by grants from the National Natural Science Foundation of China(81922071 to Y.Zhang,81872915/82073904 to M.-W.W.and 81773792/81973373 to D.Y.);the National Key Basic Research Program of China(2019YFA0508800 to Y.Zhang,2018YFA0507000 to M.-W.W.and 2018ZX09711002-002-005 to D.Y.);Zhejiang Province Science Fund for Distinguished Young Scholars(LR19H310001 to Y.Zhang);Key R&D Projects of Zhejiang Province(2021C03039 to Y.Zhang);National Science&Technology Major Project of China-Key New Drug Creation and Manufacturing Program(2018ZX09735-001 to M.-W.W.and 2018ZX09711002-002-005 to D.Y.);Novo Nordisk-CAS Research Fund(NNCAS-2017-1-CC to D.Y.).
Melanocortin-4 receptor(MC4R)plays a central role in the regulation of energy homeostasis.Its high sequence similarity to other MC receptor family members,low agonist selectivity and the lack of structural information...