不同溶出介质的多条溶出曲线评价盐酸普萘洛尔片内在质量  

Evaluation of Quality of Propranolol Hydrochloride Tablets by Dissolution Curves in Different Mediums

作　　者：刘海涛[1] 王俊秋[1] 余立[1] 

机构地区：[1]北京市药品检验所,北京100032

出　　处：《中国药业》2012年第7期15-16,共2页China Pharmaceuticals

摘　　要：目的测定21个厂家生产的盐酸普萘洛尔片在不同溶出介质中的溶出度,通过溶出曲线来评价药品内在质量。方法在4种溶出介质中,采用桨法进行溶出度试验,使用不同介质中的溶出曲线对结果进行分析和比较。结果与结论各厂家产品溶出行为差别较大,产品质量存在差异。Objective To detect the dissolution of propranolol hydrochloride tablets from different pharmaceutical factories in 4 different mediums and evaluate the quality by dissolution curves. Methods The dissolution test was carried out with paddle- rotating method. To analyse and compare the results by the dissolution curves in different mediums. Results and Conclusion There was significant dif- ference in dissolution parameters and the quality among the propranolol hydrochloride tablets preparations from different manufactories.

关 键 词：盐酸普萘洛尔片 溶出度 溶出曲线 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学] R972.2