胃癌及慢性胃病患者脾证分型与cyclinE表达的关系  

Relationship between classification of Spleen syndromes of patients with chronic gastric diseases and gastric carcinoma and cyclin E expression

作　　者：梁卫江[1] 马业俊[1] 张万岱[1] 陈永萍 

机构地区：[1]中国人民解放军第一军医大学南方医院全军消化内科研究所,广东省广州市510515

出　　处：《世界华人消化杂志》2000年第5期513-515,共3页World Chinese Journal of Digestology

基　　金：全军九五重点攻关基金资助课题;No.96Z029~~

摘　　要：目的探索胃癌、慢性胃病患者脾证分型与 cyclin E 表达的关系.方法在胃癌和慢性胃病患者中,选取具有中医脾虚表现的脾气(阳)虚、脾阴虚患者,和具有脾实表现的脾胃湿热、寒湿困脾证患者,以及按慢性浅表性胃炎、肠上皮化生、不典型增生、胃癌分组的患者,进行胃粘膜组织 cyclin E 免疫组化染色;对各证型的 cyclin E 表达进行比较,并分析 cyclin E 在常见胄粘膜病变中表达的差异.结果 cyclin E 在上述四种脾证分型的表达有显著性差异,阳性百分率分别为7.9%,27.3%,31.4%和14.3%.在慢性浅表性胄炎、肠上皮化生、不典型增生和胃癌的表达也有显著性差异,阳性率分别为7.5%,28.6%,37.9%和42.6%,后两者已较接近.结论胃癌和慢性胃病患者中,不同的中医脾证其 cyclin E 表达明显不同,在脾胃湿热和睥阴虚证型中较高,在寒湿困脾和脾气(阳)虚证型中较低.cyclin E 表达随病变由慢性浅表性胃炎、癌前病变到癌而逐渐增高,其与胃癌的发生发展密切相关.AIM To explore the relationship between classification of Spleen syndromes of patients with chronic gastric diseases and gastric carcinoma and the expression of cyclin E. METHODS The patients(n=143)with Spleen qi(yang)- deficiency,Spleen yin-deficiency,Spleen-stomach shi-re and han-shi staying in Spleen from the chronic gastric diseases or gastric carcinoma were chosen.Another group of patients(n=185)with chronic surperficial gastritis,intestinal metaplasia,dysplasia and gastric carcinoma were also chosen.With the specific and sensitive immunohistochemical staining,the expression of cyclin E in gastric mucosa tissue of the patients from the two groups were examined.The relation between classification of Spleen syndromes and the expression of cyclin E was assessed.The difference of cyclin E expression in different tissue was also analysed. RESULTS In the 4 classifications of Spleen syndromes, cyclin E was detected positive in 7.9%,27.3%,31.4% and 14.3% respectively.In different pathological tissues, cyclin E was detected in 7.5%,28.6%,37.9% and 42.6% respectively.The difference of cyclin E expressions was obvious in different classification of Spleen syndromes and pathological tissues. CONCLUSION In gastric carcinoma and chronic gastric diseases,the expression of cyclin E is stronger in Spleen- Stomach shi-re and Spleen yin-deficiency than in han-shi staying in Spleen and Spleen qi(yang)-deficiency.The expression of cyclin E gradually increase from precancerous lesions to gastric carcinoma.

关 键 词：胃肿瘤 胃疾病 脾证 CYCLIN E 表达 

分 类 号：R573[医药卫生—消化系统] R735.2[医药卫生—内科学]