1,6-二磷酸果糖钠盐结晶新工艺研究  

A New Technique for Crystallization of Octahydro Trisodium Salt of Fructose 1,6 diphosphate

作　　者：应汉杰[1] 欧阳平凯[1] 

机构地区：[1]南京化工大学生物工程与科学系,南京210009

出　　处：《化学工程》2000年第2期34-36,共3页Chemical Engineering(China)

基　　金：国家"八五"重点攻关项目!;编号为 85-0 8-0 3 -1 1

摘　　要：针对 1 ,6-二磷酸果糖 ( FDP)钠盐在酒精 -低温体系结晶时易发生初级非均相成核 ,导致产品颗粒大小不一和稳定性差的现状 ,该文通过对 FDP钠盐结晶机理的分析 ,研究了醇析和盐析相结合的结晶体系即酒精 - Na Ac体系对 FDP结晶的影响。实验发现 ,FDP在酒精 - Na Ac体系下结晶时可避免初级非均相成核的形成 ,通过调节温度或 p H来控制晶体的大小 ,结晶收率从酒精 -低温体系的 78%提高到 95%。In order to overcome elementary heterogeneous nucleation while octahydro trisodium salt of fructose 1,6 diphosphate (FDPNa 3·8H 2O) was crystallized with ethanol precipitation at low temperature,we presented a new crystallization method,alcohol precipitation combined with salt precipitation,i.e.ethanol acetate sodium system to crystallize trisodium salt of fructose 1,6 diphosphate based on the analyzing of the mechanism of crystallization of FDPNa 3·8H 2O in ethanol low temperature system.It was found that control of crystal size could be achieved by regulating crystal temperature of pH of solution during crystal process,and crystal yield was increased to 95% from 78% by comparison to ethanol low temperature system. [WT5HZ]

关 键 词：二磷酸果糖 FDP 钠盐 结晶 工艺 发酵 

分 类 号：TQ317[化学工程—高聚物工业]