原发性肺腺癌的粘液组织化学研究  

Study of the mucinohistochemistry in primary lung adenocarcinoma

作　　者：胡陆林 陈镆铘 

机构地区：[1]广州铁路中心医院病理科,广东广州510080 [2]中山医科大学孙逸仙纪念医院病理科,广东广州510120

出　　处：《癌症》2000年第2期134-136,共3页Chinese Journal of Cancer

摘　　要：目的 :研究原发性肺腺癌产生粘液物质的类型、性质及分布。方法 :收集 2 2例原发性肺腺癌进行五种粘液组化染色 ,ABpH2 .5 ,ABpH1.0 ,HID ABpH2 .5 ,ABpH2 .5 PAS ,PAS D。 结果 :2 2例均见粘液细胞型粘液 ,2 1例见被膜型粘液 (两者主要为唾液酸粘液 ) ,10例见到腺腔型粘液 (硫酸粘液为主 )。不同类型不同性质粘液可共存于同一肺腺癌中。结论 :被膜型粘液是肺腺癌一种独立类型粘液 ,与粘液细胞型粘液 ,腺腔型粘液一样对肺腺癌有诊断意义 ;不同类型不同性质粘液共存于同一肺腺癌中 ,反映了肺腺癌的异质性 ;肺腺癌主要含酸性粘液 ,ABpH2 .Objective:To study the type, character and distribution of mucin in primary lung adenocarcinoma. Methods:A total of 22 cases of primary lung adenocarcinoma were studied by 5 different kinds of mucinohistochemistry, including ABpH2.5,ABpH1.0,HID ABpH2.5,ABpH2.5 PAS,and PAS D.Results:Mucino us cell type mucin (MCM) positive carcinoma cells (primarily sialomucin) were observed in all 22 cases, surface coat type mucin(SCM) positive carcinoma cells (primarily sialomucin) in 21 cases, acinar lumen type mucin(ALM)(primarily sulfomucin) in 10 cases. Different kinds of mucin can be coexisted in the same cases. Conclusions:1.SCM is a kind of mucin existed in lung adenocarcinoma, it is helpful to the diagnosis of lung adenocarcinoma. 2. The heterogenesis of pulmonary adenocarcinoma is reflected as the coexistence of different types of mucin in the same cases. 3.The acid mucin is the major mucious component of the primary lung adenocarcinoma, and detection ABpH2.5 is simple and helpful for the diagnosis of the primary lung adenocarcinoma.

关 键 词：肺肿瘤 粘液 组织化学 肺腺癌 

分 类 号：R734.2[医药卫生—肿瘤]