卡波姆981流变学性质的研究  

Rheological characteristics of Carbopol 981

作　　者：孙士真[1] 王亚静[1] 张德芹[1] 田慧[1] 王艳明[1] 彭淑娟[1] 

机构地区：[1]天津中医药大学,天津市现代中药重点实验室-省部共建国家重点实验室培育基地,天津300193

出　　处：《天津中医药》2012年第2期177-180,共4页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市高校"双五"科技计划项目(SW20080007)

摘　　要：[目的]研究卡波姆981的流变学性质,为其在制剂中的应用提供参考。[方法]用Brookfield DV-ⅢULTRA流变仪测定不同条件下卡波姆溶液的黏度。通过与卡波姆934相比,对卡波姆981的流变学性质进行深入的探讨。[结果]卡波姆981溶液属于假塑性流体。卡波姆981对pH值、离子、机械剪切较敏感,对温度不敏感。[结论]卡波姆981对温度、离子、机械剪切的耐受性比卡波姆934要好。在制剂应用时,可以参考各条件下的流变学性质选择合适的条件。[Objective] To research the rheological characteristcs of Carbopol 981 for providing a conference in its preparation.[Methods] The viscosity of carbopol were measured under different conditions by Brookfield DV-Ⅲ ULTRA Rheometer.Through contrasting with Carbopol 934,the rheological characteristics of Carbopol 981 was deeply explored.[Results] Carbopol 981 was proved to be a false plastic fluid.It was more sensitive to pH change,ion concentration and mechanic shearing.[Conclusion] Carbopol 981 has better tolerance to temperature,ion concentration and mechanic shearing than Carbopol 934.These rheological data would be referred to choose suitable condition in the pharmaceutical preparation.

关 键 词：卡波姆981 黏度 流变学性质 

分 类 号：TQ314[化学工程—高聚物工业]