果蔬源胰脂肪酶抑制剂的筛选  

Screening Pancreatic Lipase Inhibitors from Fruits and Vegetables

作　　者：刘蕊[1,2] 张景照[3] 郑毅男[4] 徐宝军[1] 刘文丛[4] 

机构地区：[1]北京师范大学香港浸会大学联合国际学院,珠海519085 [2]香港浸会大学,香港100085 [3]贵阳医学院药学院,贵阳550004 [4]吉林农业大学中药材学院,长春130118

出　　处：《吉林农业大学学报》2012年第2期211-215,共5页Journal of Jilin Agricultural University

基　　金：吉林省科技发展计划项目(YYZX201140)

摘　　要：通过从三油酸甘油酯释放油酸的释放率来判定胰脂肪酶活性的方法,研究并比较了30种果蔬乙醇提取物的减肥作用。30种果蔬70%乙醇提取物对胰脂肪酶作用的测定结果表明:青辣椒乙醇提取物对胰脂肪酶的抑制作用最强,抑制率为46.15%,山竹提取物抑制率为29.87%,白萝卜、柠檬和圣女果提取物对胰脂肪酶的抑制率均达到20%以上。大蒜提取物对胰脂肪酶有较强的促进作用(29.64%),陈皮和山楂提取物对胰脂肪酶的促进率分别为6.38%和7.66%。The objective was to evaluate the anti-obesity effects of ethanol extracts of 30 kinds of fruits and vegetables.The authors investigated their inhibitory activity against pancreatic lipase by determining the release of oleic acid from triolein.The results showed that ethanol extract of green pepper exhibited the strongest pancreatic lipase inhibitory activity and the inhibition rate was 46.15%.The anti-lipase activity of mangosteen extract was in the second.In addition,the pancreatic lipase inhibition rate of white radish,lemon and small tomato extract exceeded 20%.However,garlic,hawthorn and orange peel extract enhanced the pancreatic lipase activity.Their pancreatic lipase promotion rates were 29.64%,7.66% and 6.38%,respectively.It is demonstrated that some fruits and vegetables extracts have the inhibitory effects against pancreatic lipase.The results provided strong theoretical basis for further investigating the inhibitory mechanism in vitro and in vivo.

关 键 词：果蔬 胰脂肪酶 减肥 甘油三酯 油酸 

分 类 号：Q946.5[生物学—植物学]