氟西汀与碳酸锂预防双相II型障碍重性抑郁发作复燃和转躁对照研究  

A control study of fluxetine versus lithium monotherapy of bipolar II disorder in rates of relapse and hypomanic mood conversion episodes

作　　者：武宁强[1] 罗海峰[1] 王奇艳[2] 李云峰[1] 

机构地区：[1]湖北省孝感市精神卫生中心,432000 [2]湖北省孝感市中心医院

出　　处：《临床精神医学杂志》2012年第2期118-119,共2页Journal of Clinical Psychiatry

摘　　要：目的:观察双相II型重性抑郁发作临床症状控制后较长期的单用氟西汀与单用碳酸锂治疗的复燃或转躁情况。方法:对75例双相II型障碍重性抑郁发作临床症状控制的患者随机分成两组,分别单用氟西汀与碳酸锂进行26周的治疗并随访,并进行汉密尔顿抑郁量表(HAMD)、杨氏躁狂量表(YMRS)评定。结果:治疗前1周、治疗2周、10周、18周、26周两组HAMD、YMRS评分两组同期比较差异均无显著性(P>0.05)。氟西汀组亚综合征抑郁和抑郁症复燃率低,碳酸锂组亚综合征轻躁狂和轻躁狂发作率低,两组比较差异均有显著性(P<0.05)。结论:双相II型障碍重性抑郁发作后氟西汀单一治疗比锂盐单一治疗可较好预防复燃,但能增加轻躁狂心境转换的发作。Objective：To compare rates of relapse and hypomanic mood conversion episodes between fluxetine and lithium monotherapy in the treatment of bipolar II disorder.Method：Patients at least 19 yeare old who recovered from major depression episode during intial open-label fluoxetine monotherapy were randomly assigned to receive 26 weeks of open-label monotherapy with fluxetine or lithium.Hamilton depression scale（HAMD） and Young mania rating scale（YMRS） were administered to all subjects at pre-and post-treatment.Results：There were no significant differences between two groups in the scores of HAMD and YMRS before 1 and after 2,10,18,26 weeks treatment,however,the rates of relapse was sigficantly lower with fluoxetine compared with lithium,the rates of hypomanic and subsyndromal hypomanic episode were sigficantly lower with lithium compared with fluoxetine（P〈0.05）.Conclusion：Fluxetine monotherapy may provide superior relapse-prevention benefit relative to lithium monotherapy after recovery from bipolar II major depressive episode,but there is an increase in hypomanic mood conversion episodes. 更多

关 键 词：双相Ⅱ型障碍 氟西汀 碳酸锂 

分 类 号：R749.4[医药卫生—神经病学与精神病学]