Synthesis of oleanolic disaccharide derivatives  

作　　者：Shu Chen Pei Jian Bo Wu Fan Lei Shan Qian Li Hai Yong Wu 

机构地区：[1]Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry,Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University,Chengdu 610041,China [2]Bioengineering College,Xihua University,Chengdu 610039,China

出　　处：《Chinese Chemical Letters》2012年第4期403-406,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Sciences Foundation of China(No.81072532);Scientific Research Fund of Sichuan Provincial Education Department(No.11205023)

摘　　要：Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities.Herein,using association principle of drug design,OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-（1→2）-a-L-arabinopyranosyl disaccharide moiety,which has proved to be a unique sugar sequence with strongly antitumor activity,and modified OA with a nitrile at C-17.Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities.Herein,using association principle of drug design,OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-（1→2）-a-L-arabinopyranosyl disaccharide moiety,which has proved to be a unique sugar sequence with strongly antitumor activity,and modified OA with a nitrile at C-17.

关 键 词：Oleanolic acid Rhamnopyranosyl Arabinopyranosyl ANTI-TUMOR Association principle 

分 类 号：TQ461[化学工程—制药化工] TQ929[轻工技术与工程—发酵工程]