五氧化二钒对雄性小鼠生殖细胞的突变性研究  

MUTAGENIC EFFECTS OF VANADIUM PENTOXIDE IN MALE MOUSE GERM CELLS

作　　者：陈艺[1] 潘晓莉[1] 杨在昌[2] 

机构地区：[1]四川省卫生管理干部学院,成都610041 [2]华西医科大学,四川成都610041

出　　处：《癌变．畸变．突变》2000年第1期53-55,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的 :研究钒及其化合物对哺乳动物雄性生殖细胞的致突变性。方法 :本研究选用雄性小鼠 ,用五氧化二钒溶液进行亚急性腹腔注射染毒。剂量为 0 .17mg/kg、2 .13mg/kg、6 .40mg/kg。观察初级精母细胞染色体畸变和早期精细胞微核率。 结果 :三受试组的初级精母细胞染色体畸变率依次为 1.4%、2 .6 % (P <0 .0 5 )、4.2 % (P <0 .0 5 ) ,有剂量反应关系 ,早期精细胞微核率依次为 2 .80‰、4.0 0‰、(P <0 .0 5 )、7.8‰ (P <0 .0 5 ) ,也有剂量反应关系。结论 :研究表明 ,五氧化二钒对哺乳动物雄性生殖细胞具有致突变性。Purpose and Methods: This paper studied the genotoxic effects of V\-2O\-5 in male mouse germ cells using structural chromosome aberrations and microncleus method. Male mice were intraperitoneally injected once every day with doses of 0.71mg/kg、2.13mg/kg、6.40mg/kg of V\-2O\-5 for 5 days. Results: In metaphase I spermatocytes, the frequencies of structfural chromosome aberration were significantly increased, which was 1.4%, 2.6%, 4.2%, respectively V\-2O\-5 significantly increased the frequencies of micronucleated early spermatids, which was 2.8‰, 4.00‰, 7.8‰, respectively. Conclusion: The results indicated that V\-2O\-5 is mutagenic activity in male mouse germ cells.

关 键 词：五氧化二钒 雄性小鼠 生殖细胞 染色体畸变 

分 类 号：R394.6[医药卫生—医学遗传学]