广西隆安县HBsAg与原发性肝癌家系调查研究  

Study on the Relationship Between HBsAg and Primary Hepatic Carcinoma Based on the Analysis of the Family Pedigree in Longan County,Guangxi

作　　者：陈钦艳[1] 王学燕[1] 方钟燎[1] 方孔雄[2] 黄坚[2] 

机构地区：[1]广西壮族自治区疾病预防控制中心,南宁市530028 [2]广西隆安县疾病预防控制中心,隆安县532700

出　　处：《广西医学》2012年第4期385-387,共3页Guangxi Medical Journal

基　　金：国家自然科学基金(30960326)

摘　　要：目的探讨广西隆安县不同家系人群HBsAg与原发性肝癌的关系。方法采用以先证者为基础的家系调查方法,根据先证者血清HBsAg检测结果和患肝癌情况,将先证者为HBsAg(+)肝癌患者的家系成员定为HBsAg(+)的肝癌组(A组),根据1∶1的匹配原则,从本村屯中选择HBsAg(+)的非肝癌及HBsAg(-)的非肝癌作为先证者调查家系成员,分别组成HBsAg(+)的非肝癌组为B组,HBsAg(-)的非肝癌组为C组。对3组先证者的一级、二级亲属进行肝癌患病情况调查,同时用ELISA法检测其HBsAg。结果 3组共调查42个家系778名家族成员,共采得血液标本246人份。HBsAg阳性率为38.62%(95/246),肝癌发病率为8.74%(68/778)。A组、B组、C组中,组内一级、二级亲属HBsAg阳性率比较差异均无统计学意义(P均>0.05);A组、B组内肝癌发病率一级亲属显著高于二级亲属(P均<0.05);C组内一、二级亲属肝癌发病率均差异无统计学意义(P>0.05)。3组间HBsAg阳性率和肝癌发病率差异均有统计学意义(P<均0.01),A、B组HBsAg阳性率高于C组(P<0.01),A组肝癌发病率高于B、C组(P<0.01)。结论先证者为HBsAg(+)且患肝癌的家系成员是HBV感染及肝癌发生的高危人群,要注意接种乙肝疫苗及预防肝癌发生。Objective To explore the relationship between HBsAg and primary hepatic carcinoma（PHC） in different family constellation people in Longan county,Guangxi.Methods Index case-based family survey was conducted.According to the detection result of HBsAg and status of PHC,family constellation members of the index case with HBsAg positive and PHC were recruited into HBsAg（＋）/PHC group（group A）.According to the 1 ∶1 matching principal,those family constellation members of index cases with HBsAg positive and non-PHC were selected to compose HBsAg（＋）/non-PHC group（group B） while the ones of HBsAg negative and non-PHC selected to HBsAg（-） non-PHC group（group C）.Results Forty two family constellations and 736 family members were investigated among 3 groups.Blood specimens of 246 cases were collected.The average positive rate of HBsAg was 38.62%（95/246）,and the average morbility of PHC was 8.74%（68/778）.No statistical significance was found in the HBsAg positive rate between first degree and second degree relative of genealogical members of index cases with HBsAg positive（P0.05）.PHC Morbility of first degree relative of genealogical members of index cases with HBsAg positive were higher than that of second degree relative in group A as well as in group B（P0.05）,but showed no statistical significance in group C（P0.05）.There was significant difference in HBsAg positive rate and PHC morbility among the three groups（P0.01）.The positive rate of HBsAg in group A,B was significantly higher than that of group C（P0.01）,and PHC morbility in group A was significantly higher than that of group B,C（P0.01）.Conclusion Family constellation members of the index cases with HBsAg positive and PHC are in the high risk of HBV infection and hepatocarcinogenesis.Hepatitis B vaccine vaccination and PHC prevention measure should be carried out.

关 键 词：原发性肝癌 高危人群 家系调查 流行病学 广西隆安县 

分 类 号：R735.7[医药卫生—肿瘤]