硒对小鼠免疫功能的影响  

Efect of Selenium on Immune Function in Immuno-suppressed Mice

作　　者：杜立芹[1] 程五凤[1] 史奎雄[1] 李宣海[1] 潘碧霞[1] 金慧芳[1] 

机构地区：[1]上海第二医科大学医学营养教研室,上海200025

出　　处：《上海第二医科大学学报》2000年第1期29-31,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市科技发展基金!954119011

摘　　要：目的探讨硒对免疫功能的影响。方法采用腹腔注射环磷酰胺的方式建立小鼠免疫功能低下模型，采用硒酵母混悬液灌胃的方式对小鼠进行补硒实验。结果补硒１μｇ／ｄ可使免疫低下小鼠血清白细胞介素２（ＩＬ－２）及干扰素水平显著增高；补硒１０μｇ／ｄ时血清抗体水平显著下降，且胸腺发生萎缩，但仍可使血清ＩＬ－２水平显著增高。结论表明补硒１μｇ／ｄ对免疫低下小鼠的免疫功能有一定增强作用，补硒达１０μｓｇ／ｄ时对免疫功能的影响尚不确定。Objective This study was to investigate the effect of selenium (Se) supplementation on the immune responses. Methods The model of immuno-suppressed mice was made by intra-peritoneal injection of cyclophosphamide. Selenium (Se) was administered by means of yeast selenium mixtures via gastricgavage. Results The levels of interleukin 2 (IL-2) and interferon in serum increased significantly when the immuno-suppressed mice were supplemented with Se 1μg/d; while Se supplementation with 10 μg/d caused atrophy of the thymus and decrement of immunoglobin in the serum of immuno-suppressed mice, but the level of IL-2 still increased significantly. Conclusion Supplementation of Se 1μg/d in the immuno-suppressed mice can increase the immune function, while a higher amount such as 10μg/d has an indefinite effect.

关 键 词：硒 免疫功能 LPO 白细胞介素2 干扰素 GPX 

分 类 号：R392.32[医药卫生—免疫学]