牛磺酸抑制高脂合并高同型半胱氨酸血症致兔动脉粥样硬化  

Taurine Restraining Atherosclerosis Induced by Hyperlipemia and Hyperhomocysteinemia in Rabbit

作　　者：袁吉祥[1] 姚成立[2] 马云海[1] 张璞璞[1] 

机构地区：[1]宁夏医科大学研究生院,宁夏银川市750004 [2]银川市第一人民医院心内科,宁夏银川市750001

出　　处：《中国动脉硬化杂志》2012年第5期435-439,共5页Chinese Journal of Arteriosclerosis

基　　金：银川市科技攻关项目资助(2010028)

摘　　要：目的研究牛磺酸拮抗高血脂合并高同型半胱氨酸血症所致动脉粥样硬化的作用及原理。方法雄性新西兰大耳白兔33只,随机分成3组:正常组、模型组、干预组。0、2、12周自兔心脏采血化验相关指标,处死兔取腹主动脉行病理学染色。结果干预组同型半胱氨酸、高密度脂蛋白胆固醇与模型组比较差异没有显著性(P>0.05),然而甘油三酯、总胆固醇、低密度脂蛋白胆固醇、氧化型低密度脂蛋白降低,差异有显著性(P<0.05)。干预组的粥样斑块面积、内皮厚度和血管细胞间黏附分子1阳性细胞百分比均较模型组明显减少(P<0.05)。结论牛磺酸作为一种内源性的细胞防护物质,虽然不能降低血清同型半胱氨酸水平,但是可以通过抑制内皮增生和血管平滑肌细胞增殖迁移、降血脂以及抗氧化应激从而拮抗动脉粥样硬化。Aim To study the role and principle of taurine in inhibiting, atherosclerosis induced by hyperlipemia and hyperhomocysteinemia in rabbit. Methods 33 healthy male New Zealand big-eared white rabbits were divided in- to 3 groups： normal, model and intervention group. Blood was drawn for laboratory test at 0, 2nd, 12th week respective- ly. The rabbits were executed and abdominal aortas were taken out for pathology dyeing at 12th week. Results Ho- mocysteine （ Hcy）, high density lipoprotein cholesterol （HDLC） of intervention group had no significant difference in com- parison with model group （P 〉 0. 05 ）. However, triglyceride （ TG）, total cholesterol （ TC）, low density lipoprotein cho- lesterol （ LDLC）, oxidized low density lipoprotein （ox-LDL） lowering had significant difference （P 〈 0. 05）. Atheroma- tous plaques area, endothelium thickness and vascular cell adhesion molecule-1 （ VCAM-1 ） positive cells percentage of in- tervention group were obviously reduced in comparison with model group （ P 〈 0. 05 ）. Conclusion Taurine, as en- dogenous cell protectiy＇e substance, may inhibit atherosclerosis through suppressing endothelial hyperplasia, vascular smooth muscle cell （VSMC） proliferation and migration, reducing hyperlipemia and suppressing oxidation stress rather than lower- ing hyperhomocysteinemia.

关 键 词：牛磺酸 高脂血症 高同型半胱氨酸血症 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]