脐带间充质干细胞治疗脊髓小脑性共济失调12例(英文)  

Transplantation of umbilical cord mesenchymal stem cells for treatment of autosomal dominant spinocerebellar ataxias in 12 cases

作　　者：邱云[1,2] 汪铮[1,2] 路红社[3] 许鹏[3] 陈文怡[3] 路延光 丁永红[3] 

机构地区：[1]上海交通大学医学院 [2]上海消化疾病研究所干细胞实验室,上海市200001 [3]解放军455医院干细胞移植中心,上海市200052

出　　处：《中国组织工程研究》2012年第14期2652-2655,共4页Chinese Journal of Tissue Engineering Research

基　　金：Pujiang Talents Plan of Shanghai Municipal Science and Technology Committee,No.09PJ1407300;the National Natural Science Foundation of China, No.30971468~~

摘　　要：背景:目前尚未见应用脐带间充质干细胞治疗脊髓小脑性共济失调的报道。目的:观察脐带间充质干细胞治疗脊髓小脑性共济失调的临床效果。方法:选择 2010-09/12 解放军 455 医院干细胞移植中心收治的 12 例脊髓小脑共济失调患者,给予脐带间充质干细胞鞘内注射, 每次 10 7 个细胞,1 次/周,4 次为 1 个疗程。结果与结论:患者治疗后 1 个月与治疗前比较国际合作共济失调评分量表评分及日常生活量表评分均明显降低(P < 0.05),提示患者的神经功能显著改善,总有效率为 16.7%。说明脐带间充质干细胞鞘内注射治疗可以在一定程度上改善脊髓小脑性共济失调患者的临床症状,提高患者生活质量。BACKGROUND：There is no study addressing transplantation of umbilical cord mesenchymal stem cells for the treatment of spinocerebellar ataxia.OBJECTIVE：To study the clinical effect of human umbilical cord stem cells transplantation in the treatment of autosomal dominant spinocerebellar ataxias.METHODS：Spinocerebellar ataxias patients selected from Stem Transplantation Center of the 455 Hospital of Chinese PLA were treated with umbilical cord mesenchymal stem cells transplantation via intrathecal injection.The number of umbilical cord mesenchymal stem cells was 10 7 per transplantation,once per week,for 4 weeks.RESULTS AND CONCLUSION：Both the total score of the International Cooperative Ataxia Rating Scale and Activities of Daily Living score were significantly decreased at 1 month after transplantation compared with before treatment（P 0.05）.The nerve function was significantly improved and the total effective rate was up to 16.7%.Experimental findings indicate that,transplantation of umbilical cord mesenchymal stem cells via intrathecal injection is a feasible and effective treatment to ameliorate the clinical efficacy of spinocerebellar ataxias patients and improve their quality of life.

关 键 词：脊髓小脑性共济失调 脐带基质 间充质干细胞 移植 

分 类 号：R394.2[医药卫生—医学遗传学]