二苯乙烯衍生物的合成及抗肿瘤活性  

Synthesis and antitumor activity of stilbene derivatives

作　　者：顾红梅[1] 张喜全[1] 徐宏江[1] 王丽[2] 李宝林[2] 

机构地区：[1]江苏正大天晴药业股份有限公司,江苏南京210042 [2]教育部药用资源与天然药物化学重点实验室,陕西师范大学化学化工学院,陕西西安710062

出　　处：《化学研究与应用》2012年第5期773-777,共5页Chemical Research and Application

摘　　要：以甲氧基取代的4’-氨基二苯乙烯与4-溴甲基-5-甲基-1,3-二氧杂环戊烯-2-酮为原料,通过亲核取代反应合成得到了4种新的二苯乙烯衍生物。这些化合物的结构经NMR、IR和元素分析确定。以HeLa、SMMC-7721、BGC-823和A549为受试细胞株,用MTT法测试了这4种化合物的抗肿瘤活性。测试结果表明,这些化合物具有一定的抗肿瘤活性。Four new stilbene derivatives were synthesized by nucleophilic substitution from substituted 4＇ -amino stilbene and 4-bro- momethyl-5-methyl-1,3-dioxolene-2-one. The structures of the compounds were characterized by elemental analysis, IR and NMR spectra. The antitumor activities of compounds were determined with MTT method. The results showed that they displayed a distinct cytotoxicity to HeLa,SMMC-7721 ,BGC-823 and A549 cells.

关 键 词：二苯乙烯衍生物 抗肿瘤活性 合成 

分 类 号：O626[理学—有机化学]