45例成人急性淋巴细胞白血病的临床和细胞遗传学分析  

Clinical and cytogenetic analyses of 45 adult patients with acute lymphoblastic leukemia

作　　者：岑岭[1] 周民[1] 陈涛[1] 肖溶[1] 杨建和[1] 姜乃可[1] 章艳[1] 卢绪章[1] 

机构地区：[1]南京医科大学附属常州第二人民医院血液科,江苏省常州市213003

出　　处：《中华医学遗传学杂志》2012年第3期356-359,共4页Chinese Journal of Medical Genetics

摘　　要：目的分析45例急性淋巴细胞白血病（acutelymphoblasticleukemia，ALL）成年患者的临床特征与染色体异常之间的相关性，探讨细胞遗传学检查在ALL的诊断及预后中的价值。方法采用荧光原位杂交检测BCR／ABL融合基因和P53基因。采用Log-rank检验比较患者的中位生存期（mediansurvivaltime，MST）。结果白细胞计数（whitebloodcellcount，WBC）≤30×10^9／L的患者MST高于WBC〉30×10^9／L者，核型正常者的MST高于核型异常者，无Ph染色体者的MST高于有Ph者，P53无缺失者MST高于P53缺失者，以上差异均有统计学意义（P〈0．05）。男女患者的MST差异无统计学意义（P〉0．05）。结论WBC是否〉30×10^9／L、核型是否异常以及是否伴Ph染色体是成人ALL患者预后的独立因素。Objective To analyze the correlation between clinical features and cytogenetic finding of 45 adult patients with acute lymphoblastic leukemia （ALL）, and to assess the value of chromosomal examination for the diagnosis and prognosis. Methods Fluorescence in situ hybridization （FISH） was utilized for detecting the BCR/ABL fusion gene and P53 gene. Median survival time （MST） of patients was compared using Log-rank test. Results Respectively, the MST of patients with white blood cell count （WBC）≤30 × 109/L, normal karyotype, or without a Philadelphia chromosome were significantly greater than those with WBC 〉 30 ）≤ 10^9/L, abnormal karyotype or Philadelphia chromosome （P〉 0. 05）. Conclusion WBC, karyotype abnormalities and presence of Philadelphia chromosome are independent factors for the prognosis of ALL in adult patients.

关 键 词：急性淋巴细胞白血病 细胞遗传学 荧光原位杂交 P53基因 预后 

分 类 号：R733.7[医药卫生—肿瘤]