连接蛋白37基因C1019T多态性与缺血性卒中及其转归的相关性  

Correlation between connex in37 C1019T polymorphism and ischemic stroke and its outcome

作　　者：刘丹[1] 孙建功[1] 孙洪英[1] 张广炜[1] 张佳[1] 王贵喜[1] 杨静[1] 宋瑞琦[1] 

机构地区：[1]包头医学院第一附属医院神经内科,014010

出　　处：《国际脑血管病杂志》2012年第4期251-256,共6页International Journal of Cerebrovascular Diseases

基　　金：基金项目：内蒙舌教育厅项目（NJl0188）

摘　　要：目的 探讨连接蛋白37（connexin37,Cx37）基因C1019T多态性与缺血性卒中及其转归的关系.方法 采用限制性片段长度多态性分析技术检测缺血性卒中组和对照组Cx37基因C1019T多态性的分布,采用改良Rankin量表（modified Rankin Scale,mRS）评价发病后3个月时神经功能转归.结果 纳入急性缺血性卒中患者232例,其中转归良好（mRS评分＜3分）210例,转归不良（mRS评分≥3分）22例；对照组235例.缺血性卒中组TT基因型（12.93％对6.39％；x2=10.087,P=0.006）和T等位基因（31.25％对21.49％;x2 =11.466,P=0.001）频率显著高于对照组.多变量logistic回归分析显示,TT基因型[优势比（odds ratio,OR）5.794,95％可信区间（confidence interval,CI）1.405～23.894;P=0.015]和T等位基因（OR 131.016,95％ CI 6.943～2472.477；P =0.001）可显著增高缺血性卒中的发病风险.单因素分析显示,TT基因型（OR 0.650,95％ CI 0.144～2.934;P=0.575）、CT基因型（OR 0.622,95％ CI 0.234～1.655；P=0.342）、CC基因型（OR 0.654,95％ CI0.268～1.595;P=0.350）与缺血性卒中转归均无显著相关性.结论 Cx37 1019TT基因型和T等位基因可增高缺血性卒中风险,T等位基因是缺血性卒中的遗传易感因素之一,但其基因多态性与缺血性卒中发病3个月时的转归无关.Objective To investigate the correlation between cornexin37 （Cx37） CI019T polymorphism and ischemic stroke and its outcome.Methods Restriction fragment length polymorphism analysis was used to detect the distribution of Cx37 C1019T polymorphism in a ischemic stroke group and a control group.The modified Rankin scale （mRS） was used to evaluate the neurological outcome at 3 months after onset.Results A total of 235 patients in the control group,and 232 patients in the ischemic stroke goup were recruited.In the ischemic stroke group,210 had a good outcome （mRS 〈3） and 22 had a poor outcome （mRS≥ 3）.The TT genotype （12.93% vs.6.39% ; x2 =10.087,P =0.006） and T allele （31.25% vs.21.49% ; x2 =11.466,P=0.001） frequency in the ischemic stroke group were significantly higher than those in the control group.Multivariatelogistic regression analysis showed that TT genotype （odds ratio [OR] 5.794; 95% confidence interval [CI] 1.405-23.894; P =0.015） and T allele （OR 131.016,95% CI 6.943 -2 472.477; P =0.001）signifkantly increased the risk of ischemic stroke.Univariate analysis showed that TT genotype （OR 0.650,95% CI 0.144 - 2,934; P =0.575）,CT genotype （OR 0.622,95% CI 0.234 - 1.655; P =0.342）,and CC genotype （OR 0.654,95% CI 0.268 - 1.595; P =0.350） had no significant correlation with the outcome of ischemic stroke.Conclusions Cx37 1019TT genotype and T allele may increase the risk of ischemic stroke.T allele is one of genetic susceptibility factors for ischemic stroke; however,its gene polymorphism is not associated with the outcome of ischemic stroke at 3 months after onset.

关 键 词：连接蛋白类 多态现象 遗传学 卒中 脑缺血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]