Design and synthesis of 4-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-1 -(4-substituted/unsubstituted benzylidene) semicarbazide:Novel agents with analgesic,anti-inflammatory and ulcerogenic properties  

作　　者：Chinnasamy Rajaram Prakash Sundararajan Raja Govindaraj Saravanan 

机构地区：[1]Department of Medicinal Chemistry,DCRM Pharmacy College,JNTUH,Andhra Pradesh,India [2]Department of Pharmaceutical Chemistry,GITAM Institute of Pharmacy,GITAM University,Vizag,Andhra Pradesh,India [3]Medicinal Chemistry Research Laboratory,Bapatla College of Pharmacy,Bapatla 522 101,Andhra Pradesh,India

出　　处：《Chinese Chemical Letters》2012年第5期541-544,共4页中国化学快报（英文版）

摘　　要：A new series of isatin semicarbazide derivatives（7a-7j） were synthesized and characterized by spectroscopic means and elemental analysis.Analgesic and anti-inflammatory screening was performed using tail-flick technique and the carrageenan-induced foot paw edema test respectively.The ulcerogenicity was also determined for all the compounds.Some of the compounds showed moderate enhancement of the activity.Among the synthesized derivatives,compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug.A new series of isatin semicarbazide derivatives（7a-7j） were synthesized and characterized by spectroscopic means and elemental analysis.Analgesic and anti-inflammatory screening was performed using tail-flick technique and the carrageenan-induced foot paw edema test respectively.The ulcerogenicity was also determined for all the compounds.Some of the compounds showed moderate enhancement of the activity.Among the synthesized derivatives,compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug.

关 键 词：ISATIN ANTI-NOCICEPTIVE Schiff base Ulcerogenicity 

分 类 号：TQ463[化学工程—制药化工]