白细胞介素-1B-511基因多态性与慢性牙周炎易感性的Meta分析  

A meta-analysis of association between interleukin-1-1B-511 polymorphism and chronic periodontitis

作　　者：李晓霞[1] 杜跃华[1] 邓嘉姝[1] 秦朴[1] 岳世超[1] 王睿[1] 

机构地区：[1]重庆医科大学附属口腔医院,重庆401147

出　　处：《现代医药卫生》2012年第10期1443-1445,1448,共4页Journal of Modern Medicine & Health

基　　金：重庆市教育委员会资助项目(KJ100315);重庆市医学重点学科建设项目资助[渝卫科教(2009)67]

摘　　要：目的探讨白细胞介素-1B-511（IL-1B-511）基因多态性与慢性牙周炎（chronic periodontitis,CP）易感性的相关性。方法系统检索中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、Pubmed、Medline和EMBase数据库,收集关于IL-1B-511基因多态性与CP易感性相关联的病例对照研究,检索时间从建库到2011年10月。纳入文章均为病例对照试验,要求研究方法相似,必须包括研究目的、设计、具体统计方法 ,其研究结果均可提供比值比（odds ra-tio,OR）及95%可信区间（95%confidence interval,95%CI）或可以换算成OR值及95%CI的基础数据,对纳入研究的文献采用基于非随机对照研究的评价量表进行质量评价,Meta分析IL-1B-511基因型的分布采用RevMan 5.1.2软件。合并效应采用ORs和95%CIs进行评价。发表偏倚通过绘制漏斗图直观判断。敏感性分析依次排除单个文献后重新进行Meta分析,估计综合效应大小。结果共10项研究纳入Meta分析,涉及病例组938名和对照组947名。Meta分析结果显示：IL-1B-511基因多态性与CP相关性而言,等位基因遗传模型基因型C等位基因与T等位基因（OR=0.98,95%CI为0.78~1.24,P=0.87）、加性遗传模型基因型C/C与T/T（OR=1.10,95%CI为0.70~1.71,P=0.69）差异均无统计学意义,显性遗传模型基因型C/T＋C/C与T/T（OR=1.10,95%CI为0.89~1.35,P=0.39）、隐性遗传模型基因型C/C与C/T＋T/T（OR=1.13,95%CI为0.91~1.39,P=0.28）差异亦无统计学意义;基于人种的亚组分析显示IL-1B-511基因多态性与白种人CP易感性相关,而没有证据显示与亚洲人种相关;基于目前研究结果,IL-1B-511基因多态性可能与CP的易感性无关,但与白种人CP易感性相关联。结论 IL-1B-511基因多态性与CP联系可能存在地域性和种族性差异,IL-1B-511基因多态性作为欧美白种人CP易感性的影响因素较为明显。Objective To study the association between the interleukin-1-1B-511（IL-1B-511）polymorphism and the susceptibility of chronic periodontitis（CP）.Methods The seystematic searches of electronic databases CBM,CNKI,Pubmed,Medline and EMBase were performed.The experiments included in the articles were the case-control experiments,and required the similar research methods which must consisted of the purpose,design and specific statistical methods,with the odds ratio（OR） and 95% confidence interval（95%CI） or converted OR values and 95% CI of the basic data.The meta-analysis was carried out by software Review Manager（version 5.1.2）.The pooled odds ratios（ORs） with 95% CIs were used to evaluayte.The different effect models were used according to the difference in heterogeneity.Publication bias was tested by funnel plot.The sensitivity analysis was made by repeating the fixed effects model or random effects model meta-analysis with each of the studies individually removed.Results A total of 10 studies including 938 cases and 947 controls were identified.Overall,no signifcant association was found between IL-1-1B-511 polymorphism and risk of chronic periodontitis when all the 10 studies pooled into the meta-analysis（for C allele vs.T allele OR=0.98,95%CI：0.78-1.24,P=0.87;for C/C vs.T/T OR=1.10,95%CI：0.70-1.71,P=0.69;for dominant model OR=1.10,95%CI：0.89-1.35,P=0.39;for recessive model：OR=1.13,95%CI：0.91-1.39,P=0.28）.In the subgroup analysis by ethnicity,significant association was found in Caucasian group but not for Asian group.Based on the results of the present study,IL-1B-511 polymorphism could not be bound up with the susceptibility to chronic periodontitis,but was associated with susceptibility to CP in the white race.Conclusion There might be the regional difference and ethnic difference between IL-1B-511 gene polymorphism and CP and IL-1B-511 gene polymorphism is an important factor to the susceptibility of CP among European-American Caucasian.

关 键 词：牙周炎 基因型 疾病遗传易感性 多态现象 遗传 白细胞介素1 META分析 

分 类 号：R781.4[医药卫生—口腔医学]