芳基丙烯酰胺类化合物的合成及其抗锥体虫半胱氨酸蛋白酶活性  

Synthesis and Their Anticruzain Activities of Arylacrylamide Compounds

作　　者：王千里[1] 程卯生[1] 王庆河[1] 宋红岩[1] 潘莉[1] 沈建民[1] 

机构地区：[1]沈阳药科大学合成二室,沈阳110015

出　　处：《中国药物化学杂志》2000年第1期33-37,共5页Chinese Journal of Medicinal Chemistry

摘　　要：设计合成了 18个芳基丙烯酰胺类化合物 ,并对其进行了抗锥体虫半胱氨酸蛋白酶的药理活性筛选 .实验表明化合物 (4) ,(8) ,(10 ) ,(11) ,(12 ) ,(14) ,(15 ) ,(16 )和 (17)的活性较强 .Eighteen arylacrylamide compounds were synthesized and their activities against cruzain in vitro were tested.The results showed that compounds (4),(8),(10),(11),(12),(14),(15),(16) and (17) had good anticruzain activities.

关 键 词：合成 芳基丙烯酰胺 半胱氨酸蛋白酶 抗寄生虫药 

分 类 号：R914[医药卫生—药物化学]