丹酚酸A对照品的制备与分析  

Preparation and analysis of salvianolic acid A reference substance

作　　者：李志刚 倪广才 渠守峰 刘严 丁锐[2] 余立[2] 

机构地区：[1]北京本草天源药物研究院,北京100039 [2]北京市药品检验所,北京100035

出　　处：《药物分析杂志》2012年第6期1013-1016,共4页Chinese Journal of Pharmaceutical Analysis

基　　金："重大新药创制"科技重大专项(2011ZX09102-002-06)

摘　　要：目的:制备丹酚酸A对照品并进行纯度分析。方法:柱层析分离纯化丹酚酸A,采用UV、IR、NMR、MS确证结构,TLC及HPLC方法检查纯度。结果:丹酚酸A纯度为99.5%。结论:丹酚酸A的纯度达到新药研究所需对照品的要求。Objective：To investigate the preparation of the reference substance of salvianolic acid A from Salvia miltiorrhiza Bge.Methods：Salvianolic acid A was isolated and purified by columns chromatography.The structure and purity of salvianolic acid A was determined by UV,IR,NMR,MS,TLC and HPLC.Results：The purity of salvianolic acid A was 99.5%.Conclusion：The purity of salvianolic acid A is agreed with the standard of the reference substance.

关 键 词：丹酚酸A 对照品 紫外吸收光谱 红外吸收光谱 核磁共振氢谱 核磁共振碳谱 质谱 高效液相色谱 薄层色谱 

分 类 号：R917[医药卫生—药物分析学]