GIi转录因子与肿瘤  

Gli Transcription Factors and Tumor

作　　者：盛晓琳[1] 洪璇[1] 陈公琰[1] 

机构地区：[1]哈尔滨医科大学附属第三医院内一科,哈尔滨市150081

出　　处：《中国肿瘤临床》2012年第12期871-873,876,共4页Chinese Journal of Clinical Oncology

摘　　要：Hedgehog(HH)信号通路参与胚胎发育、成人组织再生及修复,且在肿瘤细胞生长及转移过程中发挥重要作用。已有大量研究证实该信号通路的异常激活与多种肿瘤的发生发展密切相关。Gli是HH通路直接调控靶基因的转录因子,是该通路不同水平激活的最后共同通道,在致瘤过程中起着重要作用。Gli受多通路多因素调节,故抑制Gli靶向性治疗具有非常广阔的前景。本文对Hedgehog-Gli信号通路在恶性肿瘤发生发展中的作用、Gli转录活性的调控及致瘤作用、Gli转录因子的靶向治疗价值等方面的研究进展进行综述。The hedgehog （ HH ） signaling pathway plays an important role in the growth and metastasis of tumor cells, in addi- tion to its role in the development of the embryo and the regeneration and repair of tissues in adults. Aberrant activation of this pathway has been found to be involved in the invasion and progression of several malignant human tumors. The Gli transcription factors that di- rectly regulate the transcription of targeted genes act at the end of the Hh signaling cascade, and play an important role in carcinogene- sis. Gli has also been found to interact with other signaling pathways commonly activated in human cancers; as such, the targeted inhibi- tion of Gli-mediated transcription is likely valuable during the development of novel agents. The focus of this review is to summarize a number of the known mechanisms of HH - Gli signaling in tumor development. The review also aims to discuss its emerging role in cancer, the transcriptional activity and the carcinogenesis of Gli, major advances in the role of Gli in the HH signaling pathway, and its prospects in clinical applications.

关 键 词：HEDGEHOG GLI 转录因子 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]