脑缺血损伤机制的研究进展  

Research Advance on Mechanisms of Brain Ischemic Injury

作　　者：刘青青[1] 郭虹[1] 王少峡[1] 李美娇[1] 刘洋[1] 

机构地区：[1]天津中医药大学中医药研究院,天津市现代中药重点实验室--省部共建国家重点实验室培育基地,天津300193

出　　处：《中华中医药学刊》2012年第6期1228-1230,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：科技部国际合作项目(2009DFA31070);教育部高等学校博士学科点专项研究基金资助项目(200800630002)

摘　　要：目的:综述脑缺血损伤机制的研究进展。方法:查阅有关文献资料,并进行分析、归纳和总结。结果:脑缺血的损伤机制包括很多因素,如Ca2+超载、自由基生成增多、兴奋性氨基酸分泌、血脑屏障破坏、细胞凋亡等,研究发现各个因素之间都是相互联系,互为因果的。结论:脑缺血损伤机制的研究日益深入,为新药研发和临床治疗奠定了坚实的基础。Objective ： To summarize the development on the mechanisms of brain ischemic injury. Methods ： Consult the books and papers related, analyze and summarize. Result：There are many factors which will lead to brain ischemic injury, such as overload of Ca2＋, the increasing of free radical, the secreting of excitatory amino acid, BBB destroy, apoptosis, etc. But none of them is independent; they are all in the relationship of cause and effect. Conclusion ： The research about the mechanisms of brain isehemic iniurv attracts more and more eves as time ~oing bv. which settles the foundation of newdrag development and clinical therapy.

关 键 词：脑缺血Ca2+ 自由基 氨基酸 血脑屏障 细胞凋亡 

分 类 号：R743[医药卫生—神经病学与精神病学]