4-氨基-1-萘甲腈的合成路线改进与结构表征  

Research on Improving Synthetic Route and Structural Characterization of 4-amino-1-naphthalene Carbonitrile

作　　者：沈萍[1] 覃宇[1] 

机构地区：[1]武汉职业技术学院生物工程学院,湖北武汉430074

出　　处：《武汉职业技术学院学报》2012年第3期95-98,共4页Journal of Wuhan Polytechnic

基　　金：湖北省教育厅科学技术研究计划指导性项目(B类)"4-氨基-1-萘甲腈的合成路线改进与结构表征"(项目编号:B20016001)

摘　　要：目的改进重要的医药化工中间体4-氨基-1萘甲腈的合成路线。方法以萘胺为原料,通过氨基保护、亲核取代、氨基去保护等步骤合成了该化合物,最终产率为81.6%。结果产物结构经过元素分析、IR和1H NMR表征,证实为目标分子。结论在分子结构中引入氰基一步中,采用L-脯氨酸为催化剂,CuCN为氰基化试剂,提高了氰基化效率,降低了对环境的危害。The research aims to improve the synthetic route of 4-amino-l-naphthalene carbonitrile, which is an important pharmaceutical and chemical intermediate. The naphthylamine was used as raw materials; a compound was prepared by amino protection, nueleophilic substitution, amino unprotection and other steps. The total yield was 81.6%. Results show that the structure of the product was characterized by elemental analysis, IR and 1H NMR, which con- firmed that was the target molecule. Thus, the paper concludes that in the process of introducing cyano into the molecu- lar structure, when L-proline is used as catalyst, CuCN reagent for the cyano, the efficiency can be improved significantly and the harm to the environment can be reduced.

关 键 词：4-氨基-1-萘甲腈 L-脯氨酸 氰基化反应 催化 

分 类 号：TQ460.95[化学工程—制药化工]