L-tyrosine improves neuroendocrine function in a mouse model of chronic stress  

作　　者：Zhihua Wang Jinghua Li Zhiming Wang Lingyan Xue Yi Zhang Yingjie Chen Jun Su Zhongming Li 

机构地区：[1]Department of Emergency, Second Affiliated Hospital of Kunming Medical College, Kunming 650221, Yunnan Province, China [2]Department of Ophthalmology, Second Affiliated Hospital of Kunming Medical College, Kunming 650221, Yunnan Province, China [3]Department of Gastrointestinal Diseases, Yan-an Hospital, Kunming 650051, Yunnan Province, China [4]Second Department of Internal Medicine of Wu-hua District People＇s Hospital of Kunming, Kunming 650051, Yunnan Province China [5]Department of Anatomy, Kunming Medical University, Kunming 650031, Yunnan Province, China [6]Department of Orthopedics, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China

出　　处：《Neural Regeneration Research》2012年第18期1413-1419,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.30370537

摘　　要：Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water maze test was prolonged, serum levels of total thyrotropin and total triiodothyronine were significantly decreased, and dopamine and norepinephrine content in the pallium, hippocampus and hypothalamus were significantly reduced. All of these changes were suppressed, to varying degrees, by L-tyrosine supplementation. These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects.Adult BALB/c mice, individually housed, were stimulated with nine different stressors, arranged randomly, for 4 continuous weeks to generate an animal model of chronic stress. In chronically stressed mice, spontaneous locomotor activity was significantly decreased, escape latency in the Morris water maze test was prolonged, serum levels of total thyrotropin and total triiodothyronine were significantly decreased, and dopamine and norepinephrine content in the pallium, hippocampus and hypothalamus were significantly reduced. All of these changes were suppressed, to varying degrees, by L-tyrosine supplementation. These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects.

关 键 词：chronic unpredictable stress neuroendocrine network total thyrotropin total triiodothyronine DOPAMINE NOREPINEPHRINE L-TYROSINE neural regeneration 

分 类 号：S816.7[农业科学—饲料科学] TS261.9[农业科学—畜牧学]