遗传性非息肉病性大肠癌  

Hereditary nonpolyposis colorectal cancer: A report of 4 faimilies

作　　者：罗定存[1] 倪耀忠[1] 莫善兢[2] 陈哲京[3] 

机构地区：[1]温州市第二人民医院外科,浙江温州325028 [2]上海医科大学附属肿瘤医院外科 [3]温州医学院附属第一医院外科

出　　处：《中国癌症杂志》2000年第2期145-146,152,共3页China Oncology

摘　　要：目的 :探讨总结遗传性非息肉病性大肠癌 (HNPCC)的特征 ,提高早期诊断和治疗水平。方法 :复习文献并结合本组四个家族的临床资料进行总结分析。结果 :HNPCC发病年龄轻 ,平均发病年龄 44岁 ;约 6 5 %的患者病变发生在脾曲近侧结肠 ;约 2 5 %的患者有多原发大肠癌 ;2 0— 70 %的患者可检测到错配修复基因 (MMR)的突变 ;病理分化差但有较好的预后。结论 :HNPCC有明显的特征 。Purpose:To study the characteristics of hereditary nonpolyposis cotorectal cancer (HNPCC). Methods:Four families of HNPCC and medical literature were analyzed. Results:THe HNPCC patients were younger, with a mean age of 44 years at diagnosis. The HNPCC patients were younger, with a mean age of 44 years at diagnosis. The tumor was located to the right colon, proximal to splenic flexure in about 65% of the case, about 25 percent of cases had multiple primary colorectal cancer, and mutation of mismatch repair genes could be found in 20 to 70 percent of cases. The HNPCC had better prognosis with poor differentiation. Conclusions:The HNPCC had obvious charactistics that could be very helpful for early diagnosis and making a better basis for screening and treatment protocols.

关 键 词：遗传性非息肉病性大肠癌 HNPCC 诊断 治疗 

分 类 号：R735.34[医药卫生—肿瘤]