HPLC法测定盐酸文拉法辛胶囊有关物质  

Determination of Related Substances of Venlafaxine Hydrochloride Capsules by HPLC

作　　者：刘海涛[1] 周立春[1] 余立[1] 

机构地区：[1]北京市药品检验所,北京100032

出　　处：《中国药品标准》2012年第3期178-181,共4页Drug Standards of China

摘　　要：目的:建立测定盐酸文拉法辛胶囊有关物质的HPLC法。方法:选用C8色谱柱(4.6 mm×250 mm,5μm),流动相乙腈-0.1 mol.L-1磷酸二氢铵溶液(20∶80),检测波长为205 nm。结果:盐酸文拉法辛与有关物质分离良好,最低检测限0.8 ng。结论:方法操作简便准确,耐用性好。Objective： An HPLC method was established for determination of related substances of Venlafaxine Hydrochloride Cap- sules. Method： The chromatographic system consists of Cs column, a mixture of acetonitrile R-O. 1 mol L-1 ammonium dihydrogen phosphate R solution （20： 80） as the mobile phase. The detection wavelength was 205 nm. Results： Venlafaxine and related substances were separated. The detection limit was 0. 8 ng. Conclusion：The method was simple and accurate,and bad a good robustness.

关 键 词：盐酸文拉法辛胶囊 高效液相色谱法 有关物质 

分 类 号：R921.2[医药卫生—药学]