Two New Tirucallane-Type Triterpenoids from the Stem Barks of Aphanamixis grandifolia and Their Cytotoxic Activities  

作　　者：张耀 汪俊松 王朋然 孔令义 

机构地区：[1]State Key Laboratory of Natural Medicines,Department of Natural Medicinal Chemistry,China Pharmaceutical University,24 Tong Jia Xiang,Nanjing,Jiangsu 210009,China

出　　处：《Chinese Journal of Chemistry》2012年第6期1356-1360,共5页中国化学（英文版）

摘　　要：Two new tirucallane-type triterpenoids, 3a,24β＇,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene （I） and 3a-acetoxy-21fl-methoxy-24,25,26,27-tetranortirucall-7-ene-23（21）-lactone （2）, were isolated from the stem barks ofAphanamixis grandifblia, and their structures were elucidated on the basis of spectroscopic data analysis includ- ing ID, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines.Two new tirucallane-type triterpenoids, 3a,24β＇,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene （I） and 3a-acetoxy-21fl-methoxy-24,25,26,27-tetranortirucall-7-ene-23（21）-lactone （2）, were isolated from the stem barks ofAphanamixis grandifblia, and their structures were elucidated on the basis of spectroscopic data analysis includ- ing ID, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines.

关 键 词：tirucallane TRITERPENOID CYTOTOXICITY Aphanamixis grandi/blia meliaceae 

分 类 号：TQ464.2[化学工程—制药化工] TQ153.12