鼻内翻性乳头状瘤中Fascin的表达及与微血管密度的关系  

Expression of Fascin and correlation with MVD in sinonasal inverted papilloma

作　　者：蔡艳臣[1] 张剑[1] 

机构地区：[1]南昌大学第一附属医院耳鼻咽喉头颈外科南昌,330006

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第14期629-632,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨Fascin在鼻腔鼻窦内翻性乳头状瘤中的表达及其与微血管密度(MVD)的关系。方法:采用免疫组织化学方法检测30例鼻腔鼻窦内翻性乳头状瘤、12例鼻腔鳞状细胞癌及10例正常下鼻甲黏膜标本中Fascin的表达水平,计数CD34标记的肿瘤MVD。结果:鼻腔鼻窦内翻性乳头状瘤和鼻腔鳞状细胞癌组织中Fascin的表达分别为56.6%和83.3%,均显著高于正常下鼻甲黏膜组织20.0%(均P<0.01)。CD34标记的MVD值在下鼻甲、鼻腔鼻窦内翻性乳头状瘤、鼻腔鳞状细胞癌分别为23.64±2.74、45.10±5.45、74.76±7.32,两两比较差异均有统计学意义(均P<0.01)。Fascin表达与MVD计数呈正相关(P<0.01)。结论:Fascin的高表达以及血管生成与鼻腔鼻窦内翻性乳头状瘤的生物学行为密切相关,Fascin在鼻腔鼻窦内翻性乳头状瘤和鼻腔鳞状细胞癌的发生、发展中起重要作用,Fascin可能与血管生成在鼻腔内翻性乳头状瘤的发展中起协同作用。Objective：To investigate the expression of Fascin in sinonasal inverted papilloma（SNIP）and the re- lationship between Fascin expression and microvessel density（MVD）. Method：The expression of Fascin and CD34 were determiiaed by immunohistochemistry in 30 cases of SNIP, 12 cases of nasal squamous cell carcinoma（NSCC） and 10 cases of normal inferior turbinate（IT） tissues. Meanwhile, CD34, measure of MVD, was counted at the same time. Result：Fascin was expressed in 17 of 30（56.6%） cases of SNIP,10 of 12（83.3%） cases of NSCC and 2 of 10（20.0%） cases of normal IT tissues. Expression of Fascin was significantly increased in SNIP and NSCC compared to normal tissues（P〈0. 01）. MVD counts was 23.64±2.74,45. 10±5.45,74.76±7.32,respectively （P〈0.01）. There was a positive correlation between the expression of Fascin and MVD counts. Conclusion：The high expression of Fasein and angiogenesis are significantly associated with biological behaviour of SNIP. Fascin may play an important role in the phathogenesis of SNIP and NSCC and synergic role with angiogenesis in progres- sion of SNIP.

关 键 词：鼻肿瘤 内翻性乳头状瘤 FASCIN 微血管密度 

分 类 号：R739.6[医药卫生—肿瘤]