罗望子多糖硒酸酯的制备及表征  

Preparation and characterization of polysaccharide selenate of tamarind seeds

作　　者：高义霞[1] 袁毅君[1] 周向军[1] 王风霞[1] 张继[1,2] 

机构地区：[1]天水师范学院生命科学与化学学院,天水741001 [2]西北师范大学生命科学学院,兰州730070

出　　处：《药物分析杂志》2012年第7期1222-1226,共5页Chinese Journal of Pharmaceutical Analysis

基　　金：陇南地区灾后住宅重建与特色农产品快速生产技术集成及示范项目(2008BAK51B05);国家自然科学基金资助项目(50773064)

摘　　要：目的:合成罗望子多糖硒酸酯,并表征其结构特征。方法:在HNO3-BaCl2催化作用下,利用亚硒酸钠合成罗望子多糖硒酸酯,以硒含量为指标对合成工艺进行优选,采用红外吸收光谱、热重分析、GPC等方法对合成产物进行表征。结果:罗望子多糖硒酸酯最佳合成条件为硝酸浓度为0.5%,反应温度80℃,反应时间14 h,此条件下产物硒含量约为22 mg.g-1,结论:合成产物中硒以Se=O的形式存在,且与纯多糖比较,多糖硒酸酯热稳定性和相对分子质量稍有降低,可能是由于酸性反应体系下罗望子多糖稍有降解,同时引入的亚硒酸基对分子结构产生了影响。Objective：To synthesize and characterize polysaccharide selenate of tamarind seeds. Methods：Under the catalysis of HNOs - BaCl2, polysaccharide selenate of tamarind seeds was synthesized using sodium selenite. Se content was used as the index of investigation for optimization technology. The resultant products were characterized by infrared spectrometry, thermogravimetric analysis and GPC. Results：The results showed that the optimum synthe- sis condition were as follows：concentration of nitric acid 0. 5% ,reaction time 14 h and temperature 80 ℃. Se con- tent reached the maximium of 22 mg . g^-1. Conclusion： Se exists in the form of Se = O. The thermal stability and relative molecular weigh of polysaccharide selenate decrease slightly in contrast to pure polysaccharides, possibly due to the partial degradation of polysaccharide selenate and the introduction of sodium selenite.

关 键 词：多糖硒酸酯 罗望子 合成工艺优化 结构特征 硒含量 紫外光谱 热重分析 红外光谱 

分 类 号：R917[医药卫生—药物分析学]