四环素类抗生素降解途径及其主要降解产物研究进展  

Degradation pathways and main degradation products of tetracycline antibiotics:Research progress

作　　者：李伟明[1] 鲍艳宇[1] 周启星[1] 

机构地区：[1]南开大学环境科学与工程学院教育部环境污染过程与基准重点实验室/天津市城市生态环境修复与污染防治重点实验室,天津300071

出　　处：《应用生态学报》2012年第8期2300-2308,共9页Chinese Journal of Applied Ecology

基　　金：国家自然科学基金项目(40901259)资助

摘　　要：四环素类抗生素在生产和贮存过程中会发生一系列非生物降解反应,其中某些代谢及降解产物,与母体相比,虽然其活性降低,但毒性却大大增强.此类抗生素随着畜禽废弃物等途径进入到环境中,随环境条件的不同将发生一种或多种降解反应,其降解方式除了非生物降解外,还包括生物降解.本文综述了四环素类抗生素在不同生态环境中的降解途径以及降解产物,并对今后的研究方向进行了探计,旨在为其生态风险评价提供有价值的参考.Tetracycline antibiotics（TCs） can produce a series of abiotic degradation reactions in the process of production and storage,and some of the degradation products have lower antibacterial activity but higher toxicity,as compared to the parent antibiotics.TCs can enter the environment via the disposal of livestock and poultry wastes,and then degrade in one or more ways according to the external conditions.Besides abiotic degradation,bio-degradation also happens.This paper reviewed the degradation pathways and main degradation products of TCs in different ecological environments,and discussed the future research directions,aimed to provide valuable reference for the ecological risk assessment of the antibiotics.

关 键 词：四环素类抗生素 降解途径 降解产物 生态毒性 

分 类 号：X132[环境科学与工程—环境科学] X820.4