CPT-11联合草酸铂、5-FU方案二线治疗晚期卵巢癌的临床研究  

A combination of CPT-11,oxaliplatin and 5-FU as a second line treatment for advanced ovary cancer

作　　者：徐萍萍[1] 肖梅[1] 陈赛英[1] 

机构地区：[1]解放军第八一医院妇产科,江苏南京210002

出　　处：《现代肿瘤医学》2012年第8期1701-1703,共3页Journal of Modern Oncology

摘　　要：目的:观察CPT-11联合草酸铂、5-FU作为二线治疗晚期卵巢癌的近期疗效及不良反应。方法:25例晚期卵巢癌一线治疗失败后,行二线化疗。具体方案为草酸铂85mg/m2,iv gtt,d1,8,15;5-FU 600mg/m2,iv gtt d1-5;CPT-11 60mg/m2,iv gtt,d2,9,16。28d为1周期,2个周期后评估疗效及不良反应。结果:可评价疗效25例,其中CR 7例,PR 5例,SD 6例,PD 7例,临床获益率72%。主要不良反应为恶心、呕吐、迟发性腹泻、肝脏损害、神经毒性和骨髓抑制等。结论:CPT-11联合草酸铂、5-FU方案二线治疗晚期卵巢癌有较好的疗效,且不良反应可以耐受。Objective：To investigate the efficacy and safety of CPT - 11 combined with oxaliplatin and 5 - FU as second line treatment for advanced ovary cancer patients. Methods：All 25 advanced ovary cancer with failure first line chemotherapy ,replaced with the sencond line, the chemotherapy regimen contained oxaliplatin 85mg/m2, iv gtt, d1,s,15 ;5 - FU 600mg/m2 ,iv gtt d1-5 ;CPT - 11 60mg/m2 ,iv gtt,d2.9.16 ,every 4 weeks as a cycle. Assesment on effi- cacy and toxicity was conducted after two cycles. Results：After two cycles of treatment, 25 patients achieved partial remission,9 with stable and 16 with progressed disease. Thus, response rate was 48% （ 12/25 ） , clinical benefit rate was 72% （ 18/25 ）. Major toxicities included nausea, vomiting, delayed diarrhea, liver damage, neurological toxjcjty and myelosuppression. Conclusion： The combination of CPT - 11, oxaliplatin and 5 - FU as a second line chemothera- py for advanced ovary cancer has rational efficacy and is well tolerated.

关 键 词：晚期卵巢癌 CPT-11 草酸铂 5-FU 

分 类 号：R737.31[医药卫生—肿瘤]