肢带综合征1例及文献复习  

One Case with Limb-Girdle Syndrome: A Case Report and Literature Review

作　　者：蔡爽[1] 罗苏珊[1] 朱雯华[1] 乔凯[1] 汪寅[1] 杨柳[1] 乔向阳[1] 卢家红[1] 

机构地区：[1]复旦大学附属华山医院神经内科,200040

出　　处：《中国临床神经科学》2012年第4期413-419,共7页Chinese Journal of Clinical Neurosciences

摘　　要：目的:探讨淋巴瘤肌肉侵犯的临床特点。方法:报道1例肌肉病理确诊为淋巴瘤合并肌肉侵犯患者,对其临床、肌肉MRI表现和肌肉活检病理结果结合复习文献予以分析,总结淋巴瘤肌肉侵犯的临床特点。结果:淋巴瘤肌肉侵犯发生率较低,主要表现为受累肌肉肿块、疼痛和无力。MRI中可表现为局部肿块或弥漫性肿大及异常信号。肌肉活检及免疫组化有助于与肌炎鉴别和淋巴瘤的分型。以肌肉侵犯为主要表现的淋巴瘤化疗以CHOP方案为主,预后较好。结论:淋巴瘤肌肉侵犯可引起包括肢带综合征在内的肌病表现,有肌肉肿块或无力症状以及相应MRI表现的病例应考虑淋巴瘤肌肉侵犯可能。Aim： To explore the clinical traits in muscle invasion of lymphoma. Methods： One case of pathologically confirmed muscle invasion of lymphoma was reported. The clinical traits were summarized according to his clinical manifestations, the results of MRI, muscle biopsy and literature review. Results： Muscle invasion of lymphoma was uncommon. Major complaints might be muscle lump, pain or weakness of the muscle involved. Local mass or diffuse enlargement with abnormal muscle signal intensity could be observed on MRI. Muscle biopsy and immunohistochemical staining was helpful in differential diagnosis with inflammatory myopathy and the grouping of lymphoma. For most lymphomas with muscle invasion as the major presentation, prognosis could be satisfying with CHOP combined with other therapies. Conclusion： Muscle invasion of lymphoma can cause muscle symptoms including limb-girdle syndrome. Thus lymphoma must be taken into consideration for patients with muscle lump or weakness and corresponding MRI abnormalities.

关 键 词：淋巴瘤 肌肉 MRI 免疫组织化学 联合疗法 

分 类 号：R746[医药卫生—神经病学与精神病学] R733.4[医药卫生—临床医学]