大豆食品摄入与乳腺癌发病关系的Meta分析  

Soy food intake and breast cancer risk: a meta-analysis

作　　者：钟晓[1] 张彩霞[1] 

机构地区：[1]中山大学公共卫生学院医学统计与流行病学系,广州510080

出　　处：《卫生研究》2012年第4期670-676,共7页Journal of Hygiene Research

基　　金：国家自然科学基金资助项目(No.81102188);教育部博士点基金新教师基金项目(No.20100171120057)

摘　　要：目的探讨大豆食品摄入与乳腺癌发病的关系。方法检索1991年到2011年4月公开发表的关于大豆食品摄入与乳腺癌关系的流行病学研究进行Meta分析,结果报告合并比值比(OR)及95%可信区间(95%CI)。结果 28个研究纳入Meta分析,其中有23个病例对照研究,5个队列研究。总体分析,大豆食品摄入对乳腺癌具有保护作用(合并OR=0.86,95%CI 0.78～0.94),但按设计类型分层后,只有病例对照研究的结果显示大豆食品对乳腺癌具有保护作用(合并OR=0.86,95%CI 0.77～0.95)。在不同国家和地区人群中开展的研究结果显示,在亚洲地区人群中,合并OR=0.76(95%CI 0.67～0.87),而欧美地区人群的研究合并OR=1.01(95%CI 0.93～1.09)。对在亚洲地区人群中开展的病例对照研究和队列研究分别进行合并分析,结果显示大豆食品摄入对乳腺癌均具有保护作用,合并OR分别为0.76(95%CI 0.65～0.89)和0.81(95%CI 0.70～0.92)。但在欧美地区人群中开展的两类研究均未发现大豆食品摄入对乳腺癌有保护作用。根据绝经前后的亚组分析结果显示,仅在绝经后女性中大豆食品摄入对乳腺癌起保护作用。结论根据亚洲地区人群中开展的研究,尤其是病例对照研究结果的合并分析,提示大豆食品摄入对亚洲地区女性乳腺癌具有保护作用。Objective To explore the association of soy food intake with breast cancer risk. Methods The epidemiological studies on soy food intake and breast cancer risk published from 1991 to April 2011 were searched from MEDLINE,Pubmed, EMBASE,Sci and CNKI databases. Meta-analysis was used to estimate the combined OR and 95% CI. Results Twenty eight studies were selected for the meta-analysis, including 23 case- control studies and 5 cohort studies. The overall analysis showed that soy food intake was inversely associated with the risk of breast cancer. The pooled OR was 0.86 （95% CI 0. 78 - 0.94） for the combination of both study designs. However,the protective effect was only observed in case-control studies （the pooled OR = 0. 86,95% CI 0. 77- 0.95 ） but not in cohort studies. The protective effect of soy food intake on breast cancer risk was observed among studies conducted in Asian countries （ OR = 0. 76,95% CI 0. 67- 0.87 ） , whereas no association was found in studies from Western countries （OR = 1.01, 95% CI 0. 93-1. 09 ） . The further stratified analysis showed that the protective effect was only found in studies conducted in Asian countries （pooled OR =0.76,95% CI O. 65-0.89 for 14 case-control studies and OR = 0.81,95% CI 0.70- 0.92 for 3 cohort studies, respectively）. Additionally, the protective effect was only found among postmenopausal women but not among premenopausal women. Conclusion According to the meta-analysis of studies conducted in Asian countries, soy food intake is inversely associated with the risk of breast cancer among Asian women, especially based on the results of meta-analysis of case-control studies.

关 键 词：大豆食品 乳腺癌 META分析 

分 类 号：R737.9[医药卫生—肿瘤] TS214.2[医药卫生—临床医学]