富马酸丙二醇甲酯酶法合成工艺的研究  

Lipase-catalyzed synthesis for propylene glycol methyl fumarate

作　　者：杨恒[1] 郑建仙[1] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640

出　　处：《食品与机械》2012年第4期201-205,共5页Food and Machinery

摘　　要：以富马酸单甲酯和1,2-丙二醇为底物,采用脂肪酶催化合成富马酸丙二醇甲酯。探讨不同有机溶剂、底物摩尔比、反应温度、酶添加量、底物浓度、反应时间对产物中富马酸丙二醇甲酯相对含量的影响。结果表明,其最佳合成工艺:以叔丁醇为反应溶剂,底物摩尔比(富马酸单甲酯/1,2-丙二醇)1∶2,底物浓度1.0mol/L,酶添加量1.2%,反应温度60℃,反应时间20h。该条件下,产物中富马酸丙二醇甲酯的相对含量为63.89%。Lipase was used as catalyst to synthesize fumarate and 1,2- propylene glycol in order to obtain propylene glycol methyl fumarate （PMF）. Several factors influenced the relative content of PMF were discussed such as solvents, molar ratio of substrates, reaction tem- perature, enzyme dosage, concentration of substrates and reaction time. The results showed that the optimal reaction conditions ac- quired were tertiary butanol as solvent, the molar ratio of substrates （monomethyl fumarate： 1,2-propylene glycol） was 1 ： 2, substrates concentration was 1.0 mol/L, enzyme dosage was 1.2%, reaction temperature was 60 ℃ and the duration of reaction was 20 h. Under the optimal reaction conditions, the relative content of PMF was 63.89%.

关 键 词：富马酸单甲酯 1 2-丙二醇 脂肪酶催化 

分 类 号：TQ225.242[化学工程—有机化工]