细胞DNA含量与大肠癌临床分期及生物学特性的关系  

The Relationship of Cellular DNA Content with Clinical Stage and Biological Features of Colorectal Cancer

作　　者：邹立群[1] 毛咏秋[1] 雷松[1] 魏于全[1] 赵霞 阚兵[1] 姜愚[1] 彭枫[1] 罗锋[1] 王庆茹[1] 田聆[1] 杨莉 刘继彦[1] 

机构地区：[1]华西医科大学附属第一医院肿瘤防治中心肿瘤生物治疗科,成都610041 [2]附属第二医院妇产科

出　　处：《华西医科大学学报》2000年第2期180-182,共3页Journal of West China University of Medical Sciences

摘　　要：为进一步探讨大肠癌DNA倍体与临床分期及生物学特性的关系，采用流式细胞仪对86例大肠癌患者手术切除的新鲜大肠癌标本细胞DNA含量进行了检测。结果显示：本组病例中41例（47．7％）为二倍体；45例（53．3％）为非二倍体。DNA倍体与性别、年龄、分化程度、肿瘤部位无关，但与Dukes’分期相关，Dukes’A用肿瘤病例DNA二倍体比Dukes’B、C、D期肝癌病例更常见；Dukes’B～D期肿瘤病例之间DNA信体分布无明显差异；局部有淋巴结转移肿瘤病例DNA非二倍体更常见。提示DNA倍体与临床分期、淋巴结转移有关．The purpose of this study was to explore the relationship of cellular DNA content with clinical stage and biological features of cancer. Flow cytometry was performed on fresh specimens from 86 patients from 1997 to 1998. Forty-five (53. 3% ) specimens were found to contain cells with abnormal DNA (DNA nondiploid).Although none of the sex, age, site, differentiation variables correlated with now cytometric DNA ploidy,nondiploidy was associated with Dukes' stage and lymph node metastasis. Duke's A stage tumors were more frequently diploid than were more advanced tumors, but no difference between DUke's B, C and D stages were observed. These findings suggest that ploidy is associated with some pathological factors.

关 键 词：大肠癌 DNA倍体 临床分期 生物学特性 

分 类 号：R735.34[医药卫生—肿瘤]