VGF及其衍生肽  

VGF and its Derived Peptides

作　　者：王而强[1] 何凡[1] 曲方[1] 

机构地区：[1]沈阳军区总医院神经内科,辽宁沈阳110840

出　　处：《现代生物医学进展》2012年第23期4572-4576,共5页Progress in Modern Biomedicine

基　　金：沈阳军区总医院重点科研基金课题[06Y-Z15]

摘　　要：神经肽VGF广泛存在于中枢神经系统和外周神经系统中,在垂体、肾上腺髓质、胃肠内分泌细胞和胰岛β细胞中亦有表达。神经细胞/内分泌细胞表达VGF多肽受到神经营养因子、神经元活性等因素的调控。目前证实,VGF及其衍生肽参与生物体的能量平衡、新陈代谢以及生殖发育等的凋节。在神经系统变性病及情感性精神障碍的相关研究也日益受到关注。本文就神经肽VGF及其衍生肽的生化、生理特性及病理生理作用做一综述。The neuropeptide VGF is a widespread constituent in the central and peripheral nervous system, and also expressed in pituitary, adrenal medulla and gastrointestinal endocrine cells as well as pancreatic 13 cells. VGF peptides are expressed in Neurons and endocrine cells, which regulated by neurotrophic factor, neuronal activity and other factors. It has been confirmed that VGF and its derivatives are involved in the organism＇s energy balance, metabolism, reproductive development and other reactions. There is increasing concern for VGF peptides related research in the nervous system degeneration and affective disorder. This review summarized the biochemical and physiological characteristics of neuropeptide VGF and its derivatives and their roles in pathophysiology.

关 键 词：VGF 神经肽 VGF衍生肽 抑郁症 神经变性病 

分 类 号：R741[医药卫生—神经病学与精神病学]