艾司西酞普兰与氯咪帕明治疗抑郁症对照研究  

A comparative study of Escitalopram and Clomipramine in the treatment of Depression

作　　者：韩翠萍[1] 穆慧[1] 

机构地区：[1]淄博市第五人民医院,山东淄博255100

出　　处：《中国民康医学》2012年第15期1840-1841,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨艾司西酞普兰与氯咪帕明治疗抑郁症的疗效与安全性。方法:按入组先后分为艾司西酞普兰组和氯咪帕明组各36例,艾司西酞普兰组剂量5～20 mg/d,氯咪帕明组50～150 mg/d,疗程为8周。采用汉米尔顿抑郁量表(HAMD)评定疗效。采用体格检查、实验室检查评定其安全性。结果:艾司西酞普兰组显效率为77.8%,氯咪帕明组为75.00%,两组显效率无显著性差异(P>0.05),但艾司西酞普兰组起效快,不良反应少且轻微,患者耐受性好。结论:艾司西酞普兰治疗抑郁症疗效好,起效快且安全。Objective：To explore the efficacy and safety of Escitalopram and Clomipramine in the treatment of Depression. Methods ：72 patients were randomly divided into Escitalopram group and Clomipramine group. The dosage of Escitalopram group was 5 - 20mg/d, and the dosage of Clomipramine group was 50 - 150mg/d, the treatment period was 8 weeks. The efficacy was evaluated with HAMD and safety was evaluated physical examination and laboratory examination. Results： The efficacy rate of Escitalopram group was 77.8%, and the efficacy rate of Clomipramine group was 75% , there was no significant difference in efficacy rate between two groups （P 〉 0.05 ）, however, Escitalopram had the advantages of rapid -onset, less and slight sideeffect, and better toleration. Conclusions ： Escitalopram has the advantages of good efficacy, rapid - onset, less and slight side - effect, and better toleration in the treatment of Depression.

关 键 词：艾司西酞普兰 氯咪帕明 抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学]