儿茶素及其衍生物抗癌研究进展  

Advance in anticancer studies on catechins and their derivatives

作　　者：周洁[1,2] 龚正礼[1,2] 张凯[1,2] 丁阳平[1,2] 

机构地区：[1]西南大学食品科学学院茶学系,重庆400716 [2]重庆市农产品加工技术重点实验室,重庆400716

出　　处：《中国中药杂志》2012年第17期2510-2518,共9页China Journal of Chinese Materia Medica

基　　金：重庆市自然科学基金项目(CSTC;2010BB1134);西南大学基本科研业务费专项资金项目(XDJK2010C075);西南大学博士基金项目(SWU111040)

摘　　要：动物试验研究发现,儿茶素对不同器官肿瘤的形成及发展表现出明显的抑制作用。作用机制研究显示儿茶素通过抗氧化、抑制相关酶活性及抑制信号传导等来抑制肿瘤细胞入侵、细胞增殖、细胞血管再生及转移,并诱导细胞凋亡。该文综述了饮茶与癌症预防的相关性,概述了儿茶素及其衍生物防癌、抗癌作用机制,并对儿茶素未来的研究进行了展望。Experimental studies on animals discovered that catechins have a notable inhibitory effect on the formation and development of tumors in different organs. Studies on their mechanism showed that catechins could inhibit cancer cell invasion and proliferation, angiogenesis and metastasis and induce cancer cell apoptosis through anti-oxidation and by inhibiting related enzyme activities and cancer cell signal transmission. This essay provides an overview of correlation between tea drinking and cancer prevention, various mechanisms of catechins and their derivatives such as biochemical cancer prevention and anticancer and looks into the future of catechins.

关 键 词：儿茶素 衍生物 抗癌 流行病学研究 机制 

分 类 号：R285[医药卫生—中药学]