衰老与自噬的交互作用  

The Crosstalking Between Aging and Autophagy

作　　者：戴薇薇[1] 金国琴[1] 

机构地区：[1]上海中医药大学基础医学院生化教研室,上海201203

出　　处：《生理科学进展》2012年第4期247-250,共4页Progress in Physiological Sciences

基　　金：国家自然科学基金(30873317);上海市教委重点学科建设项目(J50301);上海市教委预算内科研项目(09JW03)资助课题

摘　　要：衰老是机体退化时期功能下降及生理紊乱的综合表现。细胞自噬是依赖溶酶体对胞质蛋白和细胞器进行降解的一种途径,自噬可以维持细胞的自我稳态或促进细胞生存。近年来从许多模式生物中的研究表明自噬与衰老之间关系密切,自噬参与衰老以及与衰老相关的各种病理过程,衰老与自噬之间存在着交互调节作用。本文就细胞自噬的形成过程、衰老与自噬的关系与作用机制作一综述。Aging is the syndrome caused by the functional decline and physiological disorder during the organism deterioration.Autophagy is the way that cells use to deliver cytoplasmic protein and organelle to lysosomes for degradation.Constitutive autophagy has a housekeeping role and is essential for survival,development and metabolic regulation.Recent studies from model organisms demonstrate that there is close relationship between aging and autophagy.Normal aging and phathological aging are often associated with a reduced autophagic potential.This paper reviewed the cross-talk between aging and autophagy,and possible molecular mechanisms as well.

关 键 词：衰老 自噬 MTOR SIRTUIN 1 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]