573例不良孕产夫妇染色体异常病例与对照组研究  

A case-control study on chromosome for couples with abnormal pregnancy

作　　者：张清健[1] 郑立新[1] 田佩玲[1] 叶嘉玲[1] 杨卫[1] 王柏贤[1] 徐珊珊[1] 周冰燚[1] 赵文忠[1] 蔡慧娜[1] 方俊宇[1] 朱志勇[1] 

机构地区：[1]广东省计划生育科学技术研究所,广东广州510600

出　　处：《中国优生与遗传杂志》2012年第9期44-45,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨不良孕产中染色体异常和多态的遗传学效应。方法对573对不良孕产夫妇与同期449对非不良孕产不孕夫妇进行染色体核型分析和统计学处理。结果染色体数目异常和Yqh+在不良孕产夫妇组与非不良孕产不孕夫妇组的发生率有统计学差异;而染色体平衡易位、罗氏易位、倒位、嵌合体以及染色体inv(9)多态在两组的发生率无统计学差异。结论染色体结构异常而非数量异常是导致不良孕产的重要原因之一,染色体多态中Yqh+也可导致不良孕产,而inv(9)不会导致不良孕产。Objective：To discuss the genetic effect of the chromosomal abnormality and chromosomal polymorphism on abnormal pregnancy.Methods： karyotype analysis and statistical treatment were conducted on 573 couples with abnormal pregnancy and 449 cases of infertile couples.Results： There were no statistical difference in the occurrence rates of balanced translocation,robertsonian translocation,inversion,mosaic and inv（9） between couples with abnormal pregnancy and infertile couples.But there were statistical difference in the occurrence rates of chromosome abnormal in number and Yqh＋ between two groups.Conclusion： Abnormal chromosomes in number is not one of the main reasons to cause abnormal pregnancy,but abnormal chromosomes in structure.Yqh＋ can cause abnormal pregnancy in the carriers,but inv（9） can not cause abnormal pregnancy in the carriers.

关 键 词：不良孕产 染色体异常 核型分析 

分 类 号：R596[医药卫生—内科学]