Thrombospondins and synaptogenesis  

作　　者：Bin Wang Weitao Guo Yun Huang 

机构地区：[1]Department of Orthopedics,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,Guangdong Province,China

出　　处：《Neural Regeneration Research》2012年第22期1737-1743,共7页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Guangdong Province,No.S2011010004096;the Medical Scientific Research Foundation of Guangdong Province,No.A2010431; A2009477

摘　　要：Here, we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions. Thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability. Thrombospondin regulates synaptogenesis through receptor a26-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells. It also participates in synaptic remodeling following injury and in the action of some nervous system drugs.Here, we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions. Thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability. Thrombospondin regulates synaptogenesis through receptor a26-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells. It also participates in synaptic remodeling following injury and in the action of some nervous system drugs.

关 键 词：THROMBOSPONDIN SYNAPSE SYNAPTOGENESIS glial cell α2δ-1 extracellular matrix neural progenitorcells Notch OPIOID regeneration neural regeneration 

分 类 号：Q425[生物学—神经生物学] S858.23[生物学—生理学]