CpG抗肿瘤作用及其免疫活性的研究进展  

Research progress on anti-tumor and immunity activity of CpG

作　　者：唐正海[1,2] 王晓文[1] 唐劲天[1] 

机构地区：[1]清华大学玉泉医院脑神经疾病研究所,北京100049 [2]北京中医药大学生物制药系

出　　处：《国际肿瘤学杂志》2012年第9期671-674,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（81071885）

摘　　要：胞嘧啶与鸟嘌呤二核苷酸序列（CpGODN）是一段以非甲基化胞嘧啶与鸟嘌呤（CpG）为核心的碱基序列，能够激活体内的多种免疫细胞，发生免疫应答，抵抗疾病。调节CpG的结构，化学修饰可提高CpG的生物活性，提高CpG作为免疫佐剂和放疗、化疗增敏剂治疗肿瘤的效果。CpG motifs are unmethylated oligodeoxynucleotides, and its core sequences are composed of unmethylated cytosine and unmethylated guanine. CpG motifs can induce the immune response by activating a variety of immune cells against diseases. The changes of CpG structure will increase the biological activities of CpG,and then enhance the therapeutic effect of CpG as the immuno adjuvant and the sensitizer of radiotherapy and chemotherapy in cancer treatment

关 键 词：CPG 免疫活性 肿瘤 

分 类 号：R730.3[医药卫生—肿瘤]