铜绿假单胞菌抗菌物质对耐甲氧西林金黄色葡萄球菌的抑菌活性研究  

Inhibitory activity of antibacterial material of Pseudomonas aeruginosa against methicillin-resistant Staphylococcus aureus

作　　者：秦金喜 李仲兴[2] 杨永昌[3] 袁欣 柏秀菊 石忻罗 

机构地区：[1]徐水县人民医院,河北徐水072550 [2]河北医科大学第二医院,河北石家庄050000 [3]北京军区总医院,北京100700

出　　处：《中国微生态学杂志》2012年第9期825-828,共4页Chinese Journal of Microecology

摘　　要：目的观察铜绿假单胞菌抗菌物质对耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcusaureus,MRSA)的体外抑菌活性。方法用交叉划线接种方法进行铜绿假单胞菌对32株耐甲氧西林金葡菌的体外抗菌活性的测定。结果铜绿假单胞菌抗菌物质对MRSA的体外抑菌活性良好,产生色素的菌株的抗菌活性最好,15株铜绿假单胞菌中,7株产蓝绿色色素的铜绿假单胞菌,对MRSA的抑制率均达到了100%,平均抑菌带的宽度为37.7 mm。结论铜绿假单胞菌抗菌物质对32株MRSA具有较强的抗菌活性,无疑对MRSA感染的抗菌药物研制方面开辟了一条新的途径。这是国内的首次研究报道。Objective To evaluate the in vitro inhibitory activity of antibacterial material of Pseudomonas aeruginosa against methicillin-resistant Staphylococcus aureus（MRSA）.Methods In vitro inhibitory activity of antibacterial material of Pseudomonas aeruginosa against 32 strains of MRSA was determined by using cross streak assay.Results In vitro inhibitory activity of antibacterial material of Pseudomonas aeruginosa against MRSA appeared satisfactory.Of the 15 strains of Pseudomonas aeruginosa,7 strains（produced blue-green pigment） showed 100% inhibition rate against MRSA,with the average diameter of inhibition zone of 37.7 mm.The antibacterial activity of pigment-producing strains was better than that of non-pigment producing strains.Conclusion The antibacterial material of Pseudomonas aeruginosa has strong antibacterial activity against the 32 strains of MRSA.This finding,which is the first reported in Chine,will pave a new way for the development of antibacterial drugs against MRSA infection.

关 键 词：铜绿假单胞菌 抗菌物质 耐甲氧西林金葡菌 抑菌活性 

分 类 号：R378.991[医药卫生—病原生物学]