Peroxiredoxin6在胃癌中的表达及其临床意义  

Expression of peroxiredoxin 6 in gastric cancer and its clinical significance

作　　者：郭红伟 吕有勇[3] 朱娅丽 杨桂彬 

机构地区：[1]北京大学航天临床医学院航天中心医院消化科,100049 [2]北京大学航天临床医学院航天中心医院综合内科,100049 [3]北京大学临床肿瘤学院北京市肿瘤防治研究所分子生物学实验室

出　　处：《中华医学杂志》2012年第34期2433-2435,共3页National Medical Journal of China

摘　　要：目的明确Peroxiredoxin6（Prx6）在胃癌中的表达及其临床意义。方法选择1992至2000年北京大学临床肿瘤学院、北京大学第一医院及内蒙古医学院的胃癌病例手术切除后的石蜡包埋组织，其中胃癌86例，癌旁形态学正常组织69例，通过查阅病理档案获取其临床病理资料；用组织微阵列和免疫组织化学染色方法检测组织中Prx6蛋白表达水平。结果Prx6以细胞质着色为主，胃癌组织中28例（32．6％）表达阳性；癌旁形态学正常组织中65例（94．2％）表达阳性（P〈0．01）。在53例高中分化胃癌组织中，21例（39．6％）Prx6高表达；在33例低分化胃癌组织中，2例（6．1％）Prx6高表达。Prx6在胃癌组织中的表达与患者的年龄、性别、病变部位、浸润深度、临床分期、血管浸润及肝转移均无明显相关性（均P〉0．05）。结论Prx6在胃癌组织中的表达低于癌旁组织，表达强弱与胃癌组织的分化程度有关。Objective To elucidate the significance of anti-oxidant protein peroxiredoxin 6 （Prx6） expression in gastric cancer （GC） tissue. Methods Eighty-six GC tissues and 69 para-cancer tissues from surgically resected specimens were included. And the clinico-pathological data were collected by reviewing medical records. Tissue microarray and immunohistochemistry （IHC） were used to detect Prx6 protein expression in tissues. Results Prx6 protein was predominantly expressed in cytoplasm. Its expression rate in GC tissues （32. 6%, n =28） was significantly lower than that in para-cancer normal tissues （94. 2%, n = 65, P 〈 0. 05 ）. And its protein overexpression rate in well and moderately-differentiated GC tissues was significantly higher than that in lowly-differentiated ones （39. 6% （21/53） vs 6. 1% （2/33）, P 〈0. 05）. Prx6 expression in gastric cancer tissues was not significantly related to age and sex of patients, lesion site, depth of invasion, clinical staging, vascular invasion and liver metastasis. Conclusions The level of Prx6 protein is lower in GC tissues than that in normal para-cancer ones. And it is significantly correlated with the differentiation degree of GC.

关 键 词：胃肿瘤 活性氧 PEROXIREDOXIN 6 

分 类 号：R735.2[医药卫生—肿瘤]