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PEROXIREDOXIN: 作品数：142被引量：439H指数：9; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：殷国荣王世鄂李少林王海龙刘转转更多>>; 相关机构：重庆医科大学山西医科大学郑州大学黑龙江八一农垦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金福建医科大学科学研究发展基金更多>>

PRDX6在心血管疾病中的研究进展: 《中国动脉硬化杂志》2024年第11期932-938,共7页谢如眉李家康姚萌格张莉; 福建省自然科学基金项目面上项目(2022J01658)。; 在心血管疾病的研究中,Peroxiredoxin 6(PRDX6)是Peroxiredoxin(PRDX)家族中唯一的哺乳动物1-Cys成员而备受关注。PRDX6因其具有过氧化酶活性和磷脂酶A2活性,在氧化应激中发挥着独特的作用,且已被证明参与氧化还原稳态、磷脂代谢。近年...; 关键词：Peroxiredoxin 6 心血管疾病氧化应激炎症

A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization: 《Acta Pharmaceutica Sinica B》2024年第7期3232-3250,共19页Ping Yu Tanwei Gu Yueyang Rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou; supported by the Guangdong Local Innovation Team Program(2019BT02Y262,China);National Natural Science Foundation of China(U20A20101,82274002,22175083);Key-Area Research and Development Program of Guangdong Province(2023B1111050008,China);National Key Research and Development Program of China(2022YFA1206900,2023YFA0914200);Science and Technology Innovation Project of Guangdong Medical Products Administration(S2021ZDZ042,2023ZDZ06,2024ZDZ08,China).; Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its pathogenesis.This study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S...; 关键词：Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

Huashi Baidu formula alleviates lipopolysaccharide-induced inflammation and acute lung injury in mice by targeting nuclear factor κB/phosphatidylinositol 3-kinase and peroxiredoxin 5被引量：1: 《Science of Traditional Chinese Medicine》2024年第1期20-28,共9页Shengnan Shen Liwei Gu Qiaoli Shi Yongping Zhu Yanqing Liu Junzhe Zhang Yuqing Meng Yinkwan Wong Wennan Luo Mengyao Jiang Ping Song Jigang Wang; This research was funded by Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(2020YFE0205100);National Natural Science Foundation of China(grant/award no.82204479);Guangdong Basic andApplied BasicResearch Foundation(grant/award no.2021A1515110381);Fundamental Research Funds for the Central public welfare research institutes(Grant No.ZZ14-YQ-056,ZZ13-YQ-103,ZZ16-ND-10-11,ZZ16-ND-10-03).; Background:Acute respiratory distress syndrome induced by acute lung injury(ALI)is the main cause for the high mortality of coronavirus disease 2019(COVID-19).Huashi Baidu formula(HSBD)with the effects of eliminating ...; 关键词：Huashi Baidu formula COVID-19 Lung injury Peroxiredoxin 5 NF-κB pathway

LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation被引量：2: 《Science China(Life Sciences)》2024年第3期488-503,共16页Xiao Fan Fangzhou Liu Xiang Wang Ying Wang Yu Chen Chengyu Shi Xinwan Su Manman Tan Qingfeng Yan Jinrong Peng Jianzhong Shao Yan Xiong Aifu Lin; supported by the National Science Fund for Distinguished Young Scholars(32225014);the National Key Research and Development Program of China(2021YFC2700903);the National Natural Science Foundation of China(81672791,81872300,82071567);Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China(LR18C060002);“Lingyan”R&D Research and Development Project(2023C03023)。; Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully e...; 关键词：long non-coding RNA PEROXIREDOXIN liquid-liquid phase separation ferroptosis breast cancer

Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway,and induces senescence in hepatocellular carcinoma被引量：1: 《Oncology Research》2024年第1期213-226,共14页XUEGANG YANG XIANHONG XIANG GUOHUI XU SHI ZHOU TIANZHI AN ZHI HUANG; National Nature Science Foundation of China(Nos.81960118,81860115,81760116 and 82060116);Guizhou Science and Technology Project:Qiankehe Foundation(No.(2020)1Y300);Natural Science Foundation of Sichuan(No.2022NSFSC0837);Science and Technology Project of Chengdu(No.2022-YF05-01811-SN);Science and Technology Project of Guizhou Province(No.YQK(2023)032);Guizhou Medical University Doctoral Start-Up Fund(No.gyfybsky-2021-27);Guizhou Medical University Doctoral Start-Up Fund(No.gyfybsky-2021-26);Guizhou Science and Technology Department(No.(2019)1259);Guizhou Science and Technology Department Guizhou Science and Technology Platform Talents(No.(2017)5718);Science and Technology Fund of Guizhou Provincial Health Commission(No.gzwki2021-382);The Affiliated Hospital of Guizhou Medical University Excellent Reserve Talent in 2023(No.gyfyxkrc-2023-06).; Hepatocellular carcinoma(HCC),a common malignancy worldwide,still lacks effective clinical treatment.The study aimed to investigate the oncogenes that affect the progression of HCC and their possible mechanisms.In our...; 关键词：Peroxiredoxin 2 Hepatocellular carcinoma Wnt/β-catenin pathway SENESCENCE PROLIFERATION

过氧化物还原酶(peroxiredoxin)家族研究进展: 《生命的化学》2023年第10期1569-1578,共10页孙豪孙晨; 山东省自然科学基金项目(ZR2020MC050)。; 过氧化物还原酶(peroxiredoxin,Prx/Prdx)是近年来发现的一个高度保守的抗氧化酶家族,参与维持细胞内活性氧平衡。Prx在原核生物、真核生物甚至古菌等所有生物体内都有分布。近年来,大量的研究表明,它们在抗氧化、信号传导、癌症发生、...; 关键词：过氧化物还原酶抗氧化免疫反应信号转导

Redox-stress response resistance(RRR)mediated by hyperoxidation of peroxiredoxin 2 in senescent cells被引量：1: 《Science China(Life Sciences)》2023年第10期2280-2294,共15页Jiao Meng Yuanyuan Wang Zhenyu Lv Xinhua Qiao Aojun Ye Qiaoli Zhu Chang Chen; the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000);the National Key Research and Development Program of China(2022YFA1303000,2022YFA1305100,2017YFA0504000);the National Natural Science Foundation of China(91849203)。; Aging is closely related to redox regulation.In our previous work,we proposed a new concept,“redox-stress response capacity(RRC),”and found that the decline in RRC was a dynamic characteristic of aging.However,the m...; 关键词：peroxiredoxin 2(PRDX2) redox-stress response capacity(RRC) redox-stress response resistance(RRR) H_(2)O_(2)sensor redox relay aging oxidative stress

Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1被引量：16: 《Signal Transduction and Targeted Therapy》2023年第3期1159-1174,共16页Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang; We are grateful to National Centre for Protein Science Shanghai for their instrument support and technical assistance.We thank the staffs from BL19U1 beamline of National Facility for Protein Science Shanghai(NFPS)at Shanghai Synchrotron Radiation Facility,for assistance during data collection.We gratefully acknowledge the financial supports from the National Key Research and Development Program of China(2020YFE0202200 to H.Z.and 2021ZD0203900 to C.L.);the project of National Multidisciplinary Innovation Team of Traditional Chinese Medicine(ZYYCXTD-202004 to C.L.);the National Natural Science Foundation of China(81903538 to H.Z.,82104064 to H.X.,91853205 to C.L.,91853206 to G.C.,81773565 to A.Z.,81972615 to Y.X.,and 21877120,22177068 to C.D.);the Postdoctoral Research Foundation of China(2019M661673 to H.Z.);the Shanghai Sailing Plan(19YF1457200 to H.Z.);the grants from Shanghai Jiao Tong University(AF1700037,WF220217002,WH101117001,and WF540162618 to A.Z.).; As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly...; 关键词：COLORECTAL cancer NUDE

过量表达Peroxiredoxin V抑制苦木提取物诱导的宫颈癌SiHa细胞凋亡: 《中国细胞生物学学报》2023年第1期35-43,共9页肖婉秋张惠娜任晨曦郭晓宇李楠丛杰冯耀元孙虎男; 2022年大学生创新创业训练计划(批准号:202210223020)资助的课题。; 近年来,宫颈癌(cervical cancer)的中药治疗方法因其低毒高效的特点备受广大研究者的关注。Prx V(Peroxiredoxin V)是Prxs(Peroxiredoxins)蛋白家族中的重要成员,在调控氧化应激诱导的癌细胞增殖、迁移、集落形成、凋亡等过程中发挥着...; 关键词：过氧化物还原酶V 苦木提取物宫颈癌细胞活性氧细胞凋亡

Effect of Peroxiredoxin 1 on the biological function of airway epithelial cells and epithelial-mesenchymal transition: 《BIOCELL》2022年第12期2671-2680,共10页HUOGEN LIU YUNDI SHI XIN WAN YING LIU HAILIN SHU FENGMING HUANG ZHENBIN GONG LING GU; The study was supported by the Fujian Provincial Science and Technology Department of the Project Fund under Grant(Grant No.2015J01573);the Medical Innovation Projects of Fujian Province’s Health and Scientific Research Talent Training Project under Grant(Grant No.2019-CXB-25).; Peroxiredoxin 1(PRDX1)participates in tumor cell proliferation,apoptosis,migration,invasion,and the epithelial-to-mesenchymal transition(EMT).This study aimed to investigate the effect of PRDX1 on the EMT of airway ep...; 关键词：Peroxiredoxin 1 Airway epithelial cell Epithelial-to-mesenchymal transition Cell migration Collagen synthesis

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