刺五加苷改善大鼠学习记忆能力的机理研究  

Mechanism Research of Acanthoside Improve Learning and Memory Abilities in Rats

作　　者：杨平[1] 李润国[1] 孟宪军[2] 

机构地区：[1]沈阳师范大学工程技术学院,辽宁沈阳110034 [2]沈阳农业大学食品学院,辽宁沈阳110161

出　　处：《食品研究与开发》2012年第9期73-75,共3页Food Research and Development

摘　　要：研究刺五加苷对大鼠学习、记忆能力改善机制。用D-半乳糖(D-gal)造成大鼠衰老模型,刺五加苷按3.6、14.4 g/kg连续灌胃56 d,Morris水迷宫法观察大鼠的学习记忆能力,检测大脑组织中超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活力,丙二醛(MDA)含量。结果表明,刺五加苷能明显提高衰老大鼠的学习记忆能力,提高脑组织SOD、GSH-Px活性,降低组织MDA含量。To research on anti-aging effect of acanthoside improve learning and memory mechanisms. Different concentrations of acanthoside treat D-galactose-induced aging rats, at the same time rats were treated with acanthoside 3.6, 14.4 g/kg by oral administration with 56 d. The Morris Water Maze is a behavioral task to test learning and memory, organizations superoxide dismutase （SOD） vitality, malondialdehyde （MDA） content were determined. Acanthoside can significantly improve learning and memory capacity, improve organizational SOD activity and lower MDA content organizations.

关 键 词：刺五加苷 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]