鼻咽炎和鼻咽癌细胞中CD147、Fascin蛋白表达  

Expression of CD147 and Fascin protein in nasopharyngitis and nasopharyngeal carcinoma

作　　者：罗爱华[1] 赵颖海[2] 景志亮[3] 姜汉国[2] 李飞虹[2] 

机构地区：[1]广东省高州市人民医院病理科,广东高州525200 [2]广东医学院基础医学院病理学教研室,广东湛江524023 [3]广东医学院附属医院病理科,广东湛江524001

出　　处：《广东医学院学报》2012年第4期361-363,共3页Journal of Guangdong Medical College

基　　金：广东省湛江市第四批科技攻关项目(No.2010C3104004)

摘　　要：目的探讨鼻咽炎和鼻咽癌细胞中CD147、Fascin蛋白表达的意义。方法用免疫组化SP法检测25例鼻咽黏膜慢性炎和30例鼻咽癌细胞中CD147和Fascin蛋白的表达。结果在鼻咽黏膜慢性炎和鼻咽癌细胞中,CD147蛋白阳性表达率分别为24.0%(6/25)和76.7%(23/30),组间差异有显著统计学意义(P<0.01);Fascin蛋白阳性表达率分别为16.0%(4/25)和93.3%(28/30),组间差异有显著统计学意义(P<0.01);30例鼻咽癌中CD147与Fascin蛋白表达呈正相关(P<0.05)。结论鼻咽癌细胞中均有CD147和Fascin蛋白过表达,可能协同参与鼻咽癌的侵袭、转移过程。Objective To investigate the significance of CD147 and fascin protein expression in nasopharyngitis and nasopharyngeal carcinoma （NPC）. Methods SP immunhistochemical method was used to detect the expression of CD147 and fascin protein in 25 cases of nasopharyngitis and 30 cases of NPC. Results The expression rate of CD147 and fascin proteins was significantly higher in NPC than that in nasopharyngitis （CD147： 76.7% vs 24.0%, P〈0.01; fascin： 93.3% vs 16.0%, P〈0.01）. There was a positive correlation between expression of CD147 and fascin protein in NPC （P〈0.05）. Conclusion Overexpression of CD147 and fascin protein is present in NPC, which could play a synergic role in the invasion and metastasis of NPC.

关 键 词：鼻咽肿瘤 FASCIN CD147 转移 

分 类 号：R739.63[医药卫生—肿瘤]