肾脏电压门控氯离子通道研究进展  

Progress of renal voltage-gated chloride channel

作　　者：赵金丽(综述)[1] 崔岚巍(审校)[1] 

机构地区：[1]哈尔滨医科大学附属第一医院儿科,150001

出　　处：《国际儿科学杂志》2012年第5期477-479,共3页International Journal of Pediatrics

基　　金：黑龙江省科技计划项目（QC07C95）;黑龙江省教育厅科学技术研究项目（11531152）;黑龙江省博士后课题（LBH-Z08132）

摘　　要：电压门控氯离子通道（voltage—gated chloride channel，C1C）是生物体内一类非常重要的氯离子通道，参与氯离子转运、细胞容量调节、细胞器酸化等病理生理过程，研究发现C1C-K与Dent病相关，CIC-5与Bartter综合征相关。该文就CIC的分类、结构、调控、在肾脏的分布及相关疾病作一综述。Voltage-gated chloride channel（CIC） is a class of very important chloride ion channels in vi- vo, participating in the chloride ion transporter., cell volume regulation, cell control acidification and many patho- logical physiological process. The studies have found that C1C-K was related to dent disease,and CIC-5 was as- sociated with bartter syndrome. This article mainly reviews C1C-type chloride ion channel classification, struc- ture, regulation and distribution in the kidney, and summarizes the related diseases.

关 键 词：电压门控氯离子通道 肾脏 Dent病 BARTTER综合征 

分 类 号：R739.63[医药卫生—肿瘤]